Deng Yiyu Male, doctor of critical care medicine, chief physician, doctoral supervisor of Southern Medical University, South China University of Technology School of Medicine, master supervisor of Shantou University School of Medicine, Deputy Chairman of the Youth Committee of the Emergency Medicine Branch of the Guangdong Medical Association, Deputy Chairman of the Fever Professional Committee of the Guangdong Traditional Chinese Medicine Association, Member of the Emergency Physician Branch of the Guangdong Medical Association, and Member of the Emergency Disaster Medical Association of the Guangdong Medical Association. He obtained a doctorate degree in medicine from the National University of Singapore Medical School in 2009, and then worked as a postdoctoral researcher at Boston Children's Hospital Affiliated to Harvard Medical School in the United States. Currently, he is the Deputy Director of ICU Area 1 Administration, Department of Emergency and Critical Care Medicine, Guangdong Provincial People's Hospital. In 2017, he was awarded as an outstanding young medical talent in Guangdong Province.
Editorial Board and Reviewer of Chinese Journal of Emergency Medicine, Reviewer of Journal of neuroscience research, Neuroscience, Neurotoxity Research, First Instance Expert of National Natural Science Foundation.
Main research areas: 1. Pathogenesis, clinical diagnosis and treatment of septic encephalopathy;2. Molecular mechanism of cerebral edema and intracranial hypertension. In recent years, more than 50 academic papers have been published in domestic and foreign journals, including 30 SCI papers, 17 as first authors or correspondence authors, with a total of over 90 impact factors. Two projects were supported by the National Natural Science Foundation of China, and two projects were supported by the Guangdong Natural Science Foundation. One project of Guangzhou Science and Technology Plan, one project of Guangdong Medical Research Fund, one project of Guangdong Provincial People's Hospital Dengfeng Plan research fund, and one project of Guangdong Outstanding Medical Young Talent Fund.
Clinical work ability: He has been working in ICU for more than ten years and can independently solve major technical problems in the field of severe medicine. He has presided over the consultation and rescue of difficult and critical patients for many times. In Guangdong Provincial People's Hospital, he is often invited by various departments for consultation to help brother departments treat critically ill patients. He went to Maoming, Shenzhen, Huizhou, Zhongshan, Qifu, Guangdong Province Second Hospital of Traditional Chinese Medicine and other hospitals for consultations to help lower-level hospitals treat difficult and critical patients. He proficiently grasp PICCO and other hemodynamic monitoring, CRRT technology and heart, lung and abdomen ultrasound technology, accurately monitor the hemodynamic status of acute and critical patients, implement accurate fluid replacement for patients, and guide the use of cardiotonic and vasoactive drugs. He is proficient in the use of various types of breathing machines, nutrition of critically ill patients, antibiotic use, patient fluid management, monitoring and protection of multiple organ functions, actively leading the development of IABP and ECOM and other technologies in departments, with outstanding ability to treat critically ill patients.
Education experience
2010 -2011:Boston Children's Hospital, Harvard Medical School, United States Postdoctoral Fellow
2006 -2009: National University of Singapore Medical School Doctor
2000 -2003: Tongji Medical College of Huazhong University of Science and Technology Master
1992 -1997: Department of Clinical Medicine, Wuhan University School of Medicine Bachelor
Research work experience
December 2016-Now: ICU, Department of Emergency and Critical Care Medicine, Guangdong People's Hospital Chief Physician
2011-November 2016: ICU, Department of Emergency and Critical Care Medicine, Guangdong Provincial People's Hospital Deputy Chief Physician
2003 -2005: ICU,Department of Emergency and Critical Care Medicine, Guangdong People's Hospital Attending physician
1997 -2000:Tongren Hospital Affiliated to Wuhan University Resident Physician
Scientific research achievement
[Major Related Research Papers Published in Recent Years] (# Represents Equal Contribution, * Represents Correspondent Author)
1.Huang P, Zhou Q, Lin Q, Lin L, Wang H, Chen X, Jiang S, Fu H, Deng Y. Complement C3a induces axonal hypomyelination in the periventricular white matter through activation of WNT/β-catenin signal pathway in septic neonatal rats experimentally induced by lipopolysaccharide. Brain Pathol. 2019 Oct 17. [Epub ahead of print] IF：6.2
2.Lin L, Chen X, Zhou Q, Huang P, Jiang S, Wang H, Deng Y*. Synaptic structure and alterations in the hippocampus in neonatal rats exposed to lipopolysaccharide. Neurosci Lett. 2019 Jul 6;709:134364. IF：2.1
3. Lin Q, Shen F, Zhou Q, Huang P, Lin L, Chen M, Chen X, Jiang S, He S, Zeng H, Deng Y*. Interleukin-1β Disturbs the Proliferation and Differentiation of Neural Precursor Cells in the Hippocampus via Activation of Notch Signaling in Postnatal Rats Exposed to Lipopolysaccharide. ACS Chem Neurosci. 2019 May 15;10 (5):2560-2575. IF：4.2
4.Chen M, Zhang M, Huang P, Lin Q, Sun C, Zeng H, Deng Y*. Novel β-lactam/β-lactamase inhibitors versus alternative antibiotics for the treatment of complicated intra-abdominal infection and complicated urinary tract infection: a meta-analysis of randomized controlled trials. Expert Rev Anti Infect Ther. 2018 Feb;16(2):111-120. IF：3.2
5. Han Q, Lin Q, Huang P, Chen M, Hu X, Fu H, He S, Shen F, Zeng H, Deng Y*. Microglia-derived IL-1β contributes to axon development disorders and synaptic deficit through p38-MAPK signal pathway in septic neonatal rats. J Neuroinflammation. 2017 Mar 14;14(1):52. IF：5.18
6. See comment in PubMed Commons belowXie D, Shen F, He S, Chen M, Han Q, Fang M, Zeng H, Chen C, Deng Y*. IL-1β induces hypomyelination in the periventricular white matter through inhibition of oligodendrocyte progenitor cell maturation via FYN/MEK/ERK signaling pathway in septic neonatal rats. Glia. 2016 Apr;64(4):583-602. IF：5.997
7.Stefanie Giera#, Yiyu Deng#, Rong Luo#, Sarah D. Ackerman, Amit Mogha, Kelly R. Monk, Yanqin Ying, Sung-Jin Jeong, Manabu Makinodan, Allison R. Bialas, Bernard S. Chang, Beth Stevens, Gabriel Corfas, and Xianhua Piao. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015 Jan 21;6: 6121. IF：11.3
8.Deng Y, Yuan J, Chi R, Ye H, Zhou D, Wang S, Mai C, Nie Z, Wang L, Zhai Y, Gao L, Zhang D, Hu L, Deng Y*, Chen C*. The Incidence, Risk Factors and Outcomes of Postoperative Acute Kidney Injury in Neurosurgical Critically Ill Patients. Sci Rep. 2017 Jun 26;7(1):4245.
9. Deng Y, Lu J, Sivakumar V, Ling EA,Kaur C. Amoeboid microglia in the periventricular white matter induce oligodendrocyte damage through expression of proinflammatory cytokines via MAP kinase signaling pathway in hypoxic neonatal rats. Brain Pathology. 2008 18(3):387-400. IF：5.256
10. Deng Y, Lu J, Ling EA, Kaur C. Monocyte chemoattractant protein-1(MCP-1) produced via NF-kappaB Signaling pathway mediates migration of amoeboid microglia in the periventricular white matter in hypoxic neonatal rats. Glia, 2009 57(6):604-621. IF：5.997
11. Deng Y, Lu J, Ling EA, Kaur C. Microglia-derived macrophage colony stimulating factor promotes generation of proinflammatory cytokines by astrocytes in the periventricular white matter in the hypoxic neonatal brain. Brain Pathology. 2010 20(5):909-925. IF：5.256
12.Deng YY*, Shen FC, Xie D, Han QP, Fang M, Chen CB, Zeng HK. Progress in Drug Treatment of Cerebral Edema. Mini Rev Med Chem. 2016;16(11):917-25. IF：2.841
13.Shen F, Han Q, Xie D, Fang M, Zeng H, Deng Y*. Efficacy and safety of tigecycline for the treatment of severe infectious diseases: an updated meta-analysis of RCTs. Int J Infect Dis. 2015 Aug 15;39:25-33. IF：1.9
14.Zhu SZ, Huang WP, Huang LQ, Han YL, Han QP, Zhu GF, Wen MY, Deng YY*, Zeng HK*. Huperzine A protects sepsis associated encephalopathy by promoting the deficient cholinergic nervous function. Neurosci Lett. 2016 Jul 8. IF：2.107
15. Deng YY*, Xie D, Fang M, Zhu GF, Chen CB, Zeng HK, Lu J, Kaur C. Astrocyte-derived proinflammatory cytokines induce hypomyelination in the periventricular white matter in the hypoxic neonatal brain. PloS one. 9(1):e87420，2014. IF：3.057
16. Deng YY*, Fang M, Zhu GF, Zhou Y, Zeng HK. Role of Microglia in the Pathogenesis of Sepsis-Associated Encephalopathy. CNS Neurol Disord Drug Targets. 2013 Sep 19. IF：3.769
17. Deng YY, Lu J, Ling EA, Kaur C. Role of microglia in the process of inflammation in the hypoxic developing brain. Front Biosci (Schol Ed). 2011 3: 884-900. IF：3.523
18.Wang Q, Deng Y, Huang L, Zeng W, Chen S, Lv B, Jiang W, Han Y, Ding H, Wen M, Zeng H. Hypertonic saline downregulates endothelial cell-derived VEGF expression and reduces blood-brain barrier permeability induced by cerebral ischaemia via the VEGFR2/eNOS pathway. Int J Mol Med. 2019 Sep;44(3):1078-1090. Epub 2019 Jul 2.
19. Ding HG, Deng YY, Yang RQ, Wang QS, Jiang WQ, Han YL, Huang LQ, Wen MY, Zhong WH, Li XS, Yang F, Zeng HK. Hypercapnia induces IL-1β overproduction via activation of NLRP3 inflammasome: implication in cognitive impairment in hypoxemic adult rats. J Neuroinflammation. 2018 Jan 5;15(1):4.
20. Huang W, Huang L, Wen M, Fang M, Deng Y, Zeng H. Long non coding RNA DILC is involved in sepsis by modulating the signaling pathway of the interleukin 6/signal transducer and activator of transcription 3/Toll like receptor 4 axis. Mol Med Rep. 2018 Dec;18(6):5775-5783.
21. Jiang W, Zhong W, Deng Y, Chen C, Wang Q, Zhou M, Li X, Sun C, Zeng H. Evaluation of a combination "lymphocyte apoptosis model" to predict survival of sepsis patients in an intensive care unit. BMC Anesthesiol. 2018 Jul 18;18(1):89.
22. Wen M, Lian Z, Huang L, Zhu S, Hu B, Han Y, Deng Y, Zeng H. Magnetic resonance spectroscopy for assessment of brain injury in the rat model of sepsis. Exp Ther Med. 2017 Nov;14(5):4118-4124.
23. Huang LQ, Zhu GF, Deng YY, Jiang WQ, Fang M, Chen CB, Cao W, Wen MY, Han YL, Zeng HK1. Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation. J Neuroinflammation. 2014 Jun 11;11:102. IF：4.667
24. Lu J, Goh SJ, Tng PY, Deng YY, Ling EA, Moochhala S. Systemic inflammatory response following acute traumatic brain injury. Front Biosci. 2009 14: 3795-3813. IF：3.523
25. Zeng HK, Wang QS, Deng YY, Fang M, Chen CB, Fu YH, Jiang WQ, Jiang X. Hypertonic saline ameliorates cerebral edema through downregulation of aquaporin-4 expression in the astrocytes. Neuroscience. 2010 166(3): 878-885. IF：3.231
26. Zeng HK, Wang QS, Deng YY, Jiang WQ, Fang M, Chen CB, Jiang X. A comparative study on the efficacy of 10% hypertonic saline and equal volume of 20% mannitol in the treatment of experimentally induced cerebral edema in adult rats. BMC Neurosci. 2010 11:153-163. IF：2.304
27. Luo R, Jin Z, Deng Y, Strokes N, Piao X. Disease-Associated Mutations Prevent GPR56-Collagen III Interaction. PLoS One. 2012 7(1):e29818. Epub 2012 Jan 4. IF：3.057
28. Huang L, Cao W, Deng Y, Zhu G, Han Y, Zeng H. Hypertonic saline alleviates experimentally induced cerebral oedema through suppression of vascular endothelial growth factor and its receptor VEGFR2 expression in astrocytes. BMC Neurosci. 2016 Oct 13;17(1):64
29. Zeng WX, Han YL, Zhu GF, Huang LQ, Deng YY, Wang QS, Jiang WQ, Wen MY, Han QP, Xie D, Zeng HK. Hypertonic saline attenuates expression of Notch signaling and proinflammatory mediators in activated microglia in experimentally induced cerebral ischemia and hypoxic BV-2 microglia. BMC Neurosci. 2017 Mar 14;18(1):32.
30. Chen SL, Deng YY, Wang QS, Han YL, Jiang WQ, Fang M, Hu B, Wu ZX, Huang LQ, Zeng HK. Hypertonic saline protects brain endothelial cells against hypoxia correlated to the levels of estimated glomerular filtration rate and interleukin-1β. Medicine (Baltimore). 2017 Jan;96(1):e5786.
31. Mengke NS, Hu B, Han QP, Deng YY, Fang M, Xie D, Li A, Zeng HK. Rapamycin inhibits lipopolysaccharide-induced neuroinflammation in vitro and in vivo. Mol Med Rep. 2016 Dec;14(6):4957-4966.
32. Zeng Hongke, Deng Yiyu. Mild hypothermia brain protection therapy after cardiopulmonary resuscitation. Chinese Journal of Emergency Medicine. 2012, 20(12): 1353-1354.
33. Deng Yiyu, Zhu Gaofeng, Zeng Hongke, Zeng Wenxin, Jiang Wenxin, Fang Ming. Effect of G protein-coupled receptor 56 on myelination of callosal axon in mouse brain. Journal of Clinical Neurology. 2014,27 (6): 437-441
34. Deng Yiyu, Zhu Gaofeng, Zeng Hongke, Zeng Wenxin, Jiang Wenxin, Fang Ming. G protein-coupled receptor 56 is involved in axonal development and myelination. Chinese Journal of Emergency Medicine. 2014,23 (6): 652-657
35. Jie Di, Zeng Hongke, Chen Chunbo *, Deng Yiyu *. Effect of IL-1β on differentiation and maturation of oligodendrocyte precursor cells in corpus callosum of septic newborn rats. Chinese Journal of Pathophysiology. 2015, 31 (3): 385-391
36. Shen Fengcai, Xie Di, Han Qianpeng, Zeng Hongke, Deng Yiyu *. Analysis of pathogenic bacteria characteristics of bloodstream infection and risk factors of mixed bloodstream infection in ICU. China Critical Care Emergency Medicine. 2015,27 (9): 718-723
37. Deng Yiyu, Han Qianpeng, Shen Fengcai, Chen Meng, Zeng Hongke. Effect of axonal dysgenesis in corpus callosum on late neurological function in septic neonatal rats. Chinese Emergency Medicine for Critical Illness. 2016, 28(8): 683-68
38. Deng Yiyu, Shen Fengcai, Lin Qiongyu, Chen Meng, Sun Cheng, Zeng Hongke. Risk Factors and Prognosis Analysis of Blood Flow Infection in Intensive Care Unit. Chinese Journal of Emergency Medicine. 2015, 24 (12): 1425-1429.
39. Deng Yiyu, Shen Fengcai, Lin Qiongyu, Chen Meng, Sun Cheng, Zeng Hongke. Analysis of pathogenic characteristics and susceptible factors of gram-negative bacilli bloodstream infection. Practical medicine. 2016, 32(4): 551-555.
[Topics Undertaking and Participating in Recent Years]
1). Study on the Occurrence Mechanism and Early Intervention Measures of Late Neurological Dysfunction Caused by Neonatal Brain Damage, ProjectNo.: DFJH201804, Scientific Research Project of Guangdong Province's "Climbing Peak Plan";The first person in charge of the project: Deng Yiyu;The project starts and ends from January 2019 to December 2022 with a grant of 500,000 yuan.
2). "molecular mechanism of il-1β mediated demyelination of white matter axons in septic newborn mice", no 81471237, funded by the national natural science foundation in 2014;The first person in charge of the project: Deng Yiyu;The project starts and ends from January 2015 to December 2018 with a grant of 700,000 yuan.
3). "Study on Molecular Mechanism of GPR 56 Regulating Myelination of White Matter Axons", No.81271329, supported by the National Natural Science Foundation in 2012;The first person in charge of the project: Deng Yiyu;The project starts and ends from January 2013 to December 2016 with a grant of 700,000 yuan.
4). "Study on the Impermeable Molecular Mechanism of Hypertonic Saline for Reducing Brain Edema" (No.81272150), supported by the National Natural Science Foundation in 2012, with Deng Yiyu as the second person in charge of the project;The project starts and ends from January 2013 to December 2016 with a grant of 700,000 yuan.
5). "Molecular Mechanism of IL-1β Originated from Microglia Causing White Matter Damage in Septic Neonatal Mice" (No.:2015A030313538), funded by Guangdong Provincial Natural Science Foundation in 2015, with Deng Yiyu as the first person in charge of the project;The project starts and ends from July 2015 to August 2018 with a subsidy of 100,000 yuan.
6). "Experimental Study on Hypertonic Saline Inhibiting Inflammatory Response of Ischemic Stroke through TLR2/NF-kB Pathway" (No.:A2013002), funded by Guangdong Medical Research Fund in 2013, with Deng Yiyu as the first person in charge of the project;Starting and ending time of the project: May 2013 to June 2015, with a subsidy of 10,000, the project has been completed.
7) Discussion on the Molecular Mechanism of Hypertonic Saline for Reducing Brain Edema Based on NKCC1,No.: S2011010002576, Guangdong Natural Science Foundation Project in 2011;Second person in charge of the project: Deng Yiyu;The project starts and ends from December 2011 to December 2013 with a subsidy of 30,000 yuan.
8) Clinical Study on Early Warning Indicators for Patients with Sepsis and Multiple Organ Dysfunction Syndrome,No.: 2005B30701011, Guangdong Science and Technology Plan Project in 2005;Second person in charge of the project: Deng Yiyu;The project starts and ends from January 2006 to December 2008.The amount of subsidy is 180,000, which has been completed.
