Specialties: Medicine

Clinical Interests: Stem cells-based therapy for cardiovascular disease.

Education:

2000.9-2005.6 Bengbu Medical College Bachelor

2005.9-2008.6 Bengbu Medical College Master

2009.10-2013. 9 The University of Hong Kong PhD

Awards and Honors

2012, The University of Hong Kong, Wong Ching Yee Scholarship

2013, The University of Hong Kong, YS and Christabel Lung ScholarshipProfessional memberships:Member of the Geriatric Group of the Emergency Branch of the Chinese Medical Association

Publications:

① Hong Y, He H, Jiang G, Zhang H, Tao W, Ding Y, Yuan D, Liu J, Fan H, Lin F, Liang X*, Li X*, Zhang Y*. miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction. Aging Cell. 2020;19(4):e13128 (IF=9.304)

② Zhang Y#, Zhang Z#, Chen P#, Ma CY, Li C, Au TYK, Tam V, Peng Y, Wu R, Cheung KMC, Sham PC, Tse HF, Chan D, Leung VY, Cheah KSE*, Lian Q*. Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem Cells. Cell Rep. 2020;30(8):2791-2806.e5 (IF=9.423)

③ Zhang Y#, Guo L#, Han S, Chen L, Li C, Zhang Z, Hong Y, Zhang X, Zhou X, Jiang D, Liang X, Qiu J, Zhang J, Li X, Zhong S, Liao C, Yan B, Tse HF, Lian Q*. Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6. Cell Death Dis. 2020;11(12):1075. (IF=8.469)

④Shi L#, Han Q#, Hong Y, Li W, Gong G, Cui J, Mao M, Liang X, Hu B, Li X*, Luo Q*, Zhang Y*. Inhibition of miR-199a-5p rejuvenates aged mesenchymal stem cells derived from patients with idiopathic pulmonary fibrosis and improves their therapeutic efficacy in experimental pulmonary fibrosis. Stem Cell Res Ther. 2021;12(1):147 (IF=6.832)

⑤ Li X#, Michaeloudes C#, Zhang Y#, Wiegman CH, Adcock IM, Lian Q*, Mak JCW*, Bhavsar PK*, Chung KF. Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways. J Allergy Clin Immunol. 2018;141(5):1634-1645.e5.( IF=14.11)⑥ Zhang H#, Zhao C#, Jiang G, Hu B, Zheng H, Hong Y, Cui Z, Shi L, Li X, Lin F, Ding Y, Wei L, Li M, Liang X*, Zhang Y*. Apelin Rejuvenates Aged Human Mesenchymal Stem Cells by Regulating Autophagy and Improves Cardiac Protection After Infarction. Front Cell Dev Biol. 2021;9:628463. (IF=6.684)