Business Address: 106 Zhongshan Er Road, Guangzhou 510080
Business Phone: 0086-20-83827812-10402
E-mail: wljgd68@163.com
Education:
Sep, 1993-Jul, 1996 Sun Yat-sen University of Medical Sciences Ph.D. Neurology Research Focus: Wilson's disease and Neurodegenerative disease
Sep, 1988-Jul, 1991 Guiyang Medical College Master degree. Neurology Research Focus: Neurodegenerative disease
Sep, 1980-Jul, 1985 Shanghai Medical Science University Bachelor degree. Clinical Medicine
Work Experience:
Jul, 1996 to Present Department of Neurology & Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences 106 Zhongshan Er Rd. Guangzhou,P.R.China Chief Physician, Professor, M.D., Ph.D.Director of Neurology Department & Guangdong Neuroscience Institute
Jun,2006-Sept,2006 Brain Research Center. The University of British Columbia(UBC)Vancouver, B.C., Canada Visiting professorSep, 1993-Jul, 1996 Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University of Medical Sciences Guangzhou, P.R.China Chief Resident Doctor and assistant Professor of Neurology
Sep, 1991-Aug, 1993 Gerontologic Institute and Department of Neurology , Affiliated Hospital Guiyang Medical CollegeGuiyang, P.R.China Chief-Neurologist and Lecturer of Neurology
Sep, 1985-Aug, 1991 Department of Neurology, Affiliated Hospital Guiyang Medical CollegeGuiyang, P.R.China Chief Resident Doctor and assistant Professor of Neurology, 1988-1991; Resident Doctor and Instructor, 1985-1988
Jul, 1984-Sep, 1985 Zhongshan Hospital, Huanshan Hospital, Mental Health Center of Shanghai, Shanghai Medical Science University, Shanghai, P.R.China. Intern
Professional Memberships:
Vice-Chairman of China Neurologist Association (CNA), Chinese Medical Doctor Association (CMDA)
Member of Chinese Society Neurology (CSN), Chinese Medical Association (CMA)
Chairman of China Parkinson's Disease and Movement Disorders Group, (CNA)
Vice-Chairman of Mobile Medical Association，Chinese Stroke Association（CSA）
Vice-Chairman of China Neurologist Association，China Medical Women's Association（CMWA）
Chairman of Cerebrovascular Physician Association, Guangdong Medical Doctor Association (GMDA)
Vice-Chairman of Neurology Association, Guangdong Medical Association (GMA)
Chairman of Parkinson's Disease and Movement Disorders Group, GMA
Member of World Stroke Organization(WSO)
Member of Movement Disorder Society(MDS)
Publications:
1. Yihui Qiu; Zhiheng Huang; Yuyuan Gao; Shujun Feng; Biao Huang; Wanyi Wang; Qihuan Xu; Jiehao Zhao; Yuhu Zhang; Limin Wang; Kun Nie; Lijuan Wang (Corresponding author); Alterations in intrinsic functional networks in Parkinson's disease patients with depression: A resting-state functional magnetic resonance imaging study, CNS neuroscience & therapeutics, 2021, 27(3): 289-298
2. Jiahui Zhang, Yuyuan Gao, Xuetao He, Shujun Feng, Jinlong Hu, Qingxi Zhang, Jiehao Zhao, Zhiheng Huang, Limin Wang, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wang (Corresponding author). Identifying Parkinson's disease with mild cognitive impairment by using combined MR imaging and electroencephalogram [J]. European radiology, 2021.
3. Ren T, Gao Y, Qiu Y, Jiang S, Zhang Q, Zhang J, Wang L, Zhang Y, Wang L (Corresponding author), Nie K. Gut Microbiota Altered in Mild Cognitive Impairment Compared With Normal Cognition in Sporadic Parkinson's Disease. Front Neurol. 2020 Feb 25;11:137.
4. Wang W, Mei M, Gao Y, Huang B, Qiu Y, Zhang Y, Wang L, Zhao J, Huang Z, Wang L (Corresponding author), Nie K. Changes of brain structural network connection in Parkinson's disease patients with mild cognitive dysfunction: a study based on diffusion tensor imaging. J Neurol. 2020 Apr;267(4):933-943.
5. Zhang J, Li Y, Gao Y, Hu J, Huang B, Rong S, Chen J, Zhang Y, Wang L, Feng S, Wang L (Corresponding author), Nie K. An SBM-based machine learning model for identifying mild cognitive impairment in patients with Parkinson's disease. J Neurol Sci. 2020 Nov 15;418:117077.
6. Qingxi Zhang; Yuyuan Gao; Jiahui Zhang; You Li; Jianing Chen; Rui Huang; Guixian Ma; Limin Wang; Yuhu Zhang; Kun Nie; Lijuan Wang (Corresponding author); L-Asparaginase Exerts Neuroprotective Effects in an SH-SY5Y-A53T Model of Parkinson's Disease by Regulating Glutamine Metabolism, Frontiers in molecular neuroscience, 2020, 13: 563054
7. Gao Y, Nie K, Duan Z, Wang S, Ma G, Zhang X, Li C, Zhang Y, Dai C, Wang L (Corresponding author). A Follow-up Study of Cerebral Microbleeds in Patients Who Received Stents for Symptomatic Cerebral Artery Stenosis. Ann Vasc Surg. 2019 Jul;58:338-346.
8. Gao Y, Tang H, Nie K, Zhu R, Gao L, Feng S, Wang L, Zhao J, Huang Z, Zhang Y, Wang L (Corresponding author). Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion[J]. Behavioural brain research. 2019;368:111885.
9. Li S, Nie K, Zhang Q, Guo M, Qiu Y, Li Y, Gao Y, Wang L (Corresponding author). Macrophage Migration Inhibitory Factor Mediates Neuroprotective Effects by Regulating Inflammation, Apoptosis and Autophagy in Parkinson's Disease[J]. Neuroscience. 2019;416:50-62.
10. Nie K, Gao Y, Mei M, Guo M, Huang Z, Wang L, Zhao J, Zhang Y, Wang L (Corresponding author). The clinical characteristics and cognitive features of mild cognitive impairment in Parkinson's disease and the analysis of relevant factors[J]. Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia. 2019;63:142-8.
11. Si Zhang; Jiehao Zhao; Yuhu Zhang; Yun Zhang; Fang Cai; Lijuan Wang (Corresponding author); Weihong Song; Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer's disease, Alzheimer's research & therapy, 2019, 11(1): 54
12. Guohua Zhang; Chengguo Zhang; Yuhu Zhang; Yukai Wang; Kun Nie; Bin Zhang; Haiqun Xie; Jiancong Lu; Lijuan Wang (Corresponding author); The effects of striatal silent lacunar infarction on the substantia nigra and movement disorders in Parkinson's disease: A follow-up study, Parkinsonism & related disorders, 2017, 43: 33-37
13. He X, Zhang Y, Chen J, Xie C, Gan R, Wang L, Wang L（Corresponding author）, Changes in theta activities in left posterior temporal region, left occipital region and right frontal region related to mild cognitive impairment in Parkinson's disease patients, Int J Neurosci, 2016, Jan 20:1-18.
14. Tang H, Huang J, Nie K, Gan R, Wang L, Zhao J, Huang Z, Zhang Y, Wang L (Corresponding author), Cognitive profile of Parkinson's disease patients: a comparative study between early-onset and late-onset Parkinson's disease, Int J Neurosci, 2016; 126(3):227-234.
15. Zhang G, Zhang Y, Zhang C, Wang Y, Ma G, Nie K, Xie H, Liu J and Wang L（Corresponding author）, Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s Disease, Parkinson's disease, 2015, 2015:1-5.
16. Li H, Zhou S, Wu L, Liu K, Zhang Y, Ma G and Wang L（Corresponding author）, The role of p38MAPK signal pathway in the neuroprotective mechanism of limb postconditioning against rat cerebral ischemia/reperfusion injury, Journal of the neurological sciences, 2015, 357(1-2):270-275.
17. Nie K, Feng SJ, Tang HM, Ma GX, Gan R, Zhao X, Zhao JH, WangLM, Huang ZH, Huang J, Gao L, Zhang YW, Zhu RM, Duan ZP, Zhang YH, Wang LJ（Corresponding author）. RIT2polymorphism is associated with Parkinson’s disease in a Han Chinese population. Neurobiol Aging. 2015 Mar;36(3):1603.e15-7.
18. Gao L, Nie K, Tang H, Wang L, Zhao J, Gan R, Huang J, Feng S, Zhu R, Duan Z, Zhang Y, Wang L（Corresponding author）. Sex differences in cognition among Chinese people with Parkinson’s disease. J Clin Neurosci.2015,22(3):488-92.
19. Gao L, Tang H, Nie K, Wang L, Zhao J, Gan R, Huang J, Feng S, Zhu R, Duan Z, Zhang Y, Zhao X, Zhang Y, Wang L（Corresponding author）.MCP-1 and CCR2 gene polymorphisms in Parkinson’s disease in a Han Chinese cohort. Neurol Sci. 2015 Apr;36(4):571-6.
20. Gao L, Tang H, Nie K, Wang L, Zhao J, Gan R, Huang J, Zhu R, Feng S, Duan Z, Zhang Y, Wang L（Corresponding author）. Cerebrospinal fluid alpha-synuclein as a biomarker for Parkinson's diseasediagnosis: a systematic review and meta-analysis. Int J Neurosci. 2015, 125(9):645-654.
21. Feng SJ, Nie K, Gan R, Huang J, Zhang YW, Wang LM, Zhao JH, Tang HM, Gao L, Zhu RM, Duan ZP, Zhang YH, Wang LJ（Corresponding author）.Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort Neurobiol Aging. 2014 Jul;35(7):1780.e11-2.
22. Wu YJ, Wang LJ（Corresponding author）, Dai CB, Ma GX, Zhang YH, Zhang X, Wu ZH. Neuroprotection by platelet-activating factor acetylhydrolase in a mouse model of transient cerebral ischemia. Neurosci Lett,2014;558(1):26-30.
23. Kun Nie; Yuhu Zhang; Biao Huang; Limin Wang; Jiehao Zhao; Zhiheng Huang; Rong Gan; Lijuan Wang. (Corresponding author) Marked N-acetylaspartate and choline metabolite changes in Parkinson’s disease patients with mild cognitive impairment. Parkinsonism Relat Disord. 2013,19(3):329-334.
24. Nie K, Zhang Y, Gan R, Wang L, Zhao J, Huang Z, Tang H, Wang L. (Corresponding author). Polymorphisms in Immune/Inflammatory Cytokine Genes are related to Parkinson’s disease with cognitive impairment in the Han Chinese Population. Neurosci Lett. 2013.541:111-115
25. Deng Bing-mei, Wang Li-juan(Corresponding author), Zhang Yu-hu, Peng Kai-run, Han Li-xin, Nie Kun, Yang Hong-jun, Zhang Li, Wang Jun. Diffusion tensor imaging reveals white matter changes associated with cognitive status in Parkinson’s disease patients. Am J Alzheimers Dis Other Demen. 2013,28(2):154-164.
26. Kun Nie, Yuhu Zhang, LiminWang, Jiehao Zhao, Zhiheng Huang, Rong Gan, Shaohua Li, Lijuan Wang (Corresponding author). A pilot study of psychometric properties of the Beijing version of Montreal Cognitive Assessment in patients with idiopathic Parkinson's disease in China. J Clin Neurosci. 2012.19(11):1497-500.
27. Xu K, Wang L, (Corresponding author) Mai J,He L. Efficacy of constraint-induced movement therapy and electrical stimulation on hand function of children with hemiplegic cerebral palsy: a controlled clinical trial.Disabil Rehabil, 2012,34:337-346.
28. Wang L, Zis O, Ma G, Shan Z, Zhang X, Wang S, Dai C, Zhao J, Lin Q, Lin S, et al. Upregulation of macrophage migration inhibitory factor gene expression in stroke. Stroke, 2009, 40:973-976.
29. Dai C, Zhang X, Wang S, Ma G, Chen Y, Zhao J, Lin S, Wang L (Corresponding author). Risk Factor Profile and Clinical Outcome of Patients with Transient Ischemic Attack or Minor Ischemic Stroke in a Prospective Hospital-Based Study. Circulation,2010,122(2): E164-165.
30. Dai C, Wang S, Zhang X, Ma G, Lin S, Wang L(Corresponding author). Stent placement in acute cerebral artery occlusion.Stroke,2009,40(7):503-504.
31. Huang XM, Dai CB, Mou ZL, Wang LJ, Wen WP,Lin SG, Xu G,Li HB.Overproduction of cyclin D1 is dependent on activated mTORC1 signal in nasopharyngeal carcinoma: implication for therapy. Cancer Lett, 2009,279(1):47-56.
32. Zhang X, Pan XL, Liu XT, Wang S, Wang LJ (Corresponding author).Down- Regulation of Platelet- Activating Factor Receptor Gene Expression During Focal Reversible Cerebral Ischemia in Rats. Neurochem Res,2007,32(3):451-456.
33. Wang L, Zheng Z, Tang A. The Study of the Diagnosis of Alzheimer’s Disease Using 18F-FDG PET. J Alzheimers Dis,2002,4(1):66.
34. Liu X, Wang W, Tang Z, Zeng W, He C, Wang L, Lu H, Li C, Zhang X, Wang S. Clinical study of PTAS therapy for patients with ischemia cerebrovascular disease caused by artery stenosis. J Huazhong Univ Sci Technolog Med Sci, 2011,31: 67-72.
35. Luo JF, Huang WH, Wang S, Dai CB, Li G, Chen JY, Zhou YL, Wang LJ. Carotid artery stenting in patients with coexistent carotid and coronary artery disease.[J]. Chin Med J (Engl),2007,120(7):608-610.
36. Dai C, Zhang X, Wang S, Ma G, Chen Y, Zhao J, Lin S, Wang L. Risk factors profile and clinical outcome of patients with transient ischemic attack or minor ischemic stroke in a prospective hospital-based study. Lancet Asia Medical forum: Stroke in Asia. 2008:75.
Academic conference papers：
1.J.N Chen, P.K He, Y.H Zhang, YY. Gao, Y.H Qiu, Y. Li, Q.X Zhang, L.M Wang, J.H Zhao, K. Nie, L.J Wang. Non-pharmacological Treatment for Parkinson’s Disease Patients with Depression: A Meta-analysis of Repetitive Transcranial Magnetic Stimulation and Cognitive-Behavioral Treatment [abstract]. Mov Disord. 2020; 35 (suppl 1)
2.P. He, L. Wang, J. Chen, Y. Zhang, Y. Gao, Q. Xu, Y. Qiu, H. Cai, Y. Li, Z. Huang, S. Feng, J. Zhao, G. Ma, K. Nie, L. Wang. Repetitive transcranial magnetic stimulation (rTMS) fails to improve cognition in patients with Parkinson’s disease: a meta-analysis of randomized controlled trials [abstract]. Mov Disord. 2020; 35 (suppl 1).
3.Y. Li, YY. Gao, K. Nie, L.J Wang. Potential Diagnosis Biomarks in Serum Biochemical items of Vascular Parkinsonism Patients [abstract]. Mov Disord. 2020; 35 (suppl 1).
4.J.H Zhang, L.J Wang, K. Nie. Multimodal EEG-MRI based machine learning model in identifying Parkinson’s disease with mild cognitive impairment [abstract]. Mov Disord. 2020; 35 (suppl 1).
5.Q.X Zhang, Y.Y Gao, L.J Wang. Cerebral microvascular injury provoked by alpha-synuclein preformed brils exacerbates cognitive dysfunction in Parkinson’s disease [abstract]. Mov Disord. 2020; 35 (suppl 1)
6.H.L Wang, YY. Gao, L.J Wang. Vascular factors in Parkinson’s disease with cognitive impairment [abstract]. Mov Disord. 2020; 35 (suppl 1)
7.Nie K, Gao Y, Mei M, Guo M, Huang Z, Wang L, Zhao J, Zhang Y, Wang L*. The clinical characteristics and cognitive features of mild cognitive impairment in Parkinson’s disease and analysis of relevant factors [abstract]. The Movement Disorder Society’s 22nd International Congress of Parkinson`s Disease and Movement Disorders 2018, Hong Kong, P.R. China, 2018.10.05-10.09. Poster. Mov Disord. 2018; 33 (suppl 2).
8.Nie K, Mei M, Gao Y, Guo M, Huang B, Huang Z, Wang L, Zhao J, Zhang Y, Xiong D, Wang L*. Relationships between specific subtypes of mild cognitive impairment and grey matter atrophy in Parkinson's disease [abstract]. The Movement Disorder Society’s 22nd International Congress of Parkinson`s Disease and Movement Disorders 2018, Hong Kong, P.R. China, 2018.10.05-10.09. Poster. Mov Disord. 2018; 33 (suppl 2).
9.Y. Gao, H. Tang, K. Nie, R. Zhu, L. Gao, S. Feng, L. Wang, J. Zhao, Z. Huang, Y. Zhang, L. Wang. Microglial activation, white matter and hippocampal damage correlate with cognitive impairment in chronic cerebral hypoperfused and MPTP-lesioned mice [abstract]. The Movement Disorder Society’s 22nd International Congress of Parkinson`s Disease and Movement Disorders 2018, Hong Kong, P.R. China, 2018.10.05-10.09. Poster. Mov Disord. 2018; 33 (suppl 2).
10.Gao Y , Nie K, Mei M, Guo M, Huang Z, Wang L, Zhao J, Huang B, Zhang Y, Wang L*. Changes in cortical thickness in patients with early Parkinson’s disease at different Hoehn and Yahr stages [abstract]. The Movement Disorder Society’s 22nd International Congress of Parkinson`s Disease and Movement Disorders 2018, Hong Kong, P.R. China, 2018.10.05-10.09. Poster. Mov Disord. 2018; 33 (suppl 2).
11.K. Nie, M. Mei, Y. Gao, M. Guo, B. Huang, Z. Huang, L. Wang, J. Zhao, Y. Zhang, D. Xiong, L. Wang. Relationships between specific subtypes of mild cognitive impairment and grey matter atrophy in Parkinson’s disease [abstract]. The Movement Disorder Society’s 22nd International Congress of Parkinson`s Disease and Movement Disorders 2018, Hong Kong, P.R. China, 2018.10.05-10.09. Poster. Mov Disord. 2018; 33 (suppl 2).
12. Feng SJ, Zhang YH, Wang LJ, Dystonic tremor presenting as parkinsonian tremor: a case report, The 14th Asian & Oceanian Congress of Neurology, AOCN 2014. (Oral presentation)13. Nie K, Zhang Y, Huang B, Wang L, Zhao J, Huang Z, Gan R, Wang L, Marked N-acetylaspartate and choline metabolite changes in Parkinson’s disease patients with mild cognitive impairment, The Movement Disorder Society’s 16th International Congress of Parkinson’s Disease and Movement Disorders, Dublin, Ireland, June 17-21, 2012, Poster.
14. Nie K, Zhang Y, Huang B, Wang L, Zhao J, Huang Z, Gan R, Wang L, Occipital lobe and posterior cingulate metabolic changes occur in Parkinson's disease with the mild cognitive impairment, the XIX World Congress on Parkinso’s disease and Related Disorders, Shanghai, China, Decebmer 11-14, 2011, Poster.
15. Nie K, Zhang Y, Wang L, Zhao J, Huang Z, Gan R, Li S, Wang L, Validation of the Beijing version of the Montreal Cognitive Assessment (BJ-MoCA) for Parkinson´s disease: results from a Chinese pilot study, the XIX World Congress on Parkinson’s disease and Related Disorders, Shanghai, China, Decebmer 11-14, 2011, Poster.
16. Wang L, The diagnosis and treatment of dystonia, the XIX World Congress on Parkinson’s disease and Related Disorders, Shanghai, China, Decebmer 11-14, 2011, Oral Presentation.
17. Dai C, Zhang X, Wang S, Ma G, Chen Y, Zhao J, Lin S, Wang L, Risk Factor Profile and Clinical Outcome of Patients with Transient Ischemic Attack or Minor Ischemic Stroke in a Prospective Hospital-Based Study, Circulation,2010,122(2): E164-E165 P311.
18. Dai C,Wang L, Wang S, Zhang X ,Ma G, Zhang Y, Zhao J, Lin S, Clinical outcomes of acute ischemic stroke patients with late recanalization after unsuccessful intra-arterial thrombolysis, International J of Stroke, 5 (Suppl.2).7th World Stroke Congress, Seoul Korea, 2010,10,13-16. Poster
19. Zhang X,Dai CB,Wang S,Ma GX,Zhang YH,Wang LJ, The Intervention Effects of Recombinant Human Platelet-Activating Factor Acetylhydrolase on Platelet Function in Rats with Acute Microcirculatory Disturbance, International J of Stroke, 5 (Suppl.2).7th World Stroke Congress, Seoul Korea, 2010,10,13-16. Poster
20. Zhang X, Dai CB, Ma GX, Wang S, Wu YJ, Wang LJ, The study of recombinant human platelet activating factor acetylhydrolase for treatment of cerebral infarction in rats, International J of Stroke, 5 (Suppl.2).7th World Stroke Congress, Seoul Korea, 2010,10,13-16. Poster
