Specialties: Rheumatology and Immunology
Clinical Interests: Pathogenesis and biological therapy of autoimmune diseases, especially Rheumatoid Arthritis and Systemic Lupus Erythematosus.
Bio: 1998- 2001, Visiting Scholar, Department of Immunology, Tokushima University, Japan. 2004- 2005, Attending Physician, Department of Rheumatology and Immunology, The Second Affiliated Hospital of Harbin Medical University. 2005- 2011, Deputy Director, Associate Professor, Department of Rheumatology and Immunology, The Second Affiliated Hospital of Harbin Medical University. 2009 – May 2021, Chief Physician, Professor and Director (from 2011) of the Department of Rheumatology and Immunology, The Second Affiliated Hospital of Harbin Medical University, also in charge of the national key clinical specialty construction project (2013). June 2021 – present, Director and Chief Physician, Department of Rheumatology and Immunology, Guangdong Provincial People's Hospital.
Education: 1989- 1995 Undergraduate student in Harbin Medical University. 1995 - 1998 Master degree candidate in Harbin Medical University. 2001 - 2004, Ph.D. candidate in Graduate School of Medical Sciences, Kyushu University, Japan.
Awards and Honors: She has received three grants from National Natural Science Foundation, three sub-projects of the National High-tech Research and Development Program. She was awarded the "May 1" Labor Medal of Heilongjiang Province in 2011.
Professional memberships: Member of the 8th - 10th session of Chinese Association of Rheumatology and Immunology. Member of Rheumatology and Immunology Branch of Chinese Medical Doctor Association. Standing member of the Immunosorbent Academic Committee, Chinese Medical Doctor Association. The evaluation expert of the National Natural Science Foundation of China, the National High-tech Research and Development Program of China, the doctoral program fund of the Ministry of Education.
Publications: ( First and corresponding author in recent 5 years)
1.Su J, Han X, Yang F, Song Y, Lei H, Wang X, Fan X, Li Y (corresponding author). Application of Automated Hand Ultrasound Scanning and a Simplified 3-Joint Scoring System for Assessment of Rheumatoid Arthritis Activity. Ultrasound in Medicine & Biology. 2021, Accepted.
2.Wang XY, Chen ZF, Fan XM, Li W, Qu JQ, Dong C, Wang ZX, Ji ZW, Li Y (corresponding author). Inhibition of DNM1L and mitochondrial fission attenuates inflammatory response in fibroblast-like synoviocytes of rheumatoid arthritis. J Cell Mol Med. 2020, 24:1516-1528.
3.Zhang Y, Lei H, Zhu S, Li W, Lin J, Zhang J, Li Y (corresponding author), Jin P. In vivo monitoring of rashes caused by systemic lupus erythematosus disease using snapshot spectral imaging. Journal of Biophotonics. 2020 Mar;13(3):e201960067. doi: 10.1002/jbio.201960067
4.Yan M, Su J, Li Y (corresponding author). Rheumatoid arthritis-associated bone erosions: evolving insights and promising therapeutic strategies. Biosci Trends. 2020; 14(5): 342-348.
5.Li W, Liu Y, Zheng X, Gao J, Wang L, Li Y (corresponding author). Investigation of the Poten2tial Use of Sialic Acid as a Biomarker for Rheumatoid Arthritis. Ann Clin Lab Sci 2019;49:224-231.
6.Yang F, Fan X, Huang H, Dang Q, Lei H, Li Y (corresponding author). A single microorganism epitope attenuates the development of murine autoimmune arthritis: regulation of dendritic cells the mannose receptor, Front Immunol 2018, 9: 1528-1543.
7.Huang H, Lei H, Yang F, Fan X, Dang Q, Li Y (corresponding author). Activation of the bile acid receptor GPBAR1 (TGR5) ameliorates interleukin-1beta (IL-1beta)-induced chondrocytes senescence. Biomedicine & pharmacotherapy. 2018, 106:1713-1719
8.Dai Q, Li Y (corresponding author), Yu H, Wang X. Suppression of Th1 and Th17 Responses and induction of Treg responses by IL-18-expressing plasmid gene combined with IL-4 on collagen-induced arthritis. Biomed Research International, 2018, 2018: 5164715
9.Rana A K, Li Y (corresponding author) et al. Monocytes in rheumatoid arthritis: circulating precursors of macrophages and osteoclasts and their heterogeneity and plasticity role in RA pathogenesis. International Immunopharmacology, 2018, 65: 348-359
10.Yan M, Liu X, Li Y (corresponding author), et al. Intra-articular injection of human synovial membrane-derived mesenchymal stem cells in murine collagen-induced arthritis: assessment of immunomodulatory capacity in vivo. Stem Cells International, 2017, 2017: 9198328
11.Lei H, Wang J, Dang Q, Yang, Liu X, Zhang J, Li Y (corresponding author). Neuropsychiatric involvement in lupus is associated with the Nogo-a/NgR1 pathway. Journal of neuroimmunology, 2017, 311: 22-28
12.Dang Q, Yang F, Lei H, Liu X, Yan M, Huang H, Fan X, Li Y (corresponding author). Inhibition of microRNA-34a ameliorates murine collagen-induced arthritis, Experimental and therapeutic medicine, 2017, 14: 1633-1639.
