Specialties:paediatric critical care medicine(PCCM) and neurology.
Clinical Interests:
Pediatric emergency,criticalcare medicine and clinical and basic research on pediatric neurological diseases;
Organ function assessment and support technology, genetic etiology and pathogenesis of intellectual disability and epilepsy.
Bio:
Postgraduate tutor of southern medical university and Guangdong Cardiovascular Institute.
7/2000-11/2006,resident,department of pediatrics,guangdong provincial people's hospital.
12/2006-11/2011,attending doctor of pediatrics,guangdongprovincial people's hospital.
12/2011-10/2015,associate chief doctor of PICU,guangdongprovincial people's hospital.
11/2016,obtained chief physician qualification.
4/2021-present,deputy director of pediatrics and director of PICU in guangdongprovincial people’shospital(GDPH)
In2011, obtained certificate of amplitude EEG monitoringtechnique in Cork university maternity hospital.
In2016,clinical training certificate of braininjury quality control and evaluation center of national health and family planning commission.
In 2017,training certificate of pediatric fundamental critical care support.
Education:Bachelor of medical science, Sun Yat-senuniversity of medical sciences.
Master and doctor of medical science southern medical university.
Awards and Honors:the outstanding young medical talent of guangdong province
high-level talent evaluation expert in guangdong province
guangdong province technology project evaluation expert
guangzhou science and technology project evaluation exper
advanced worker in the fight against SARS
excellent clinical teacher of Sun Yat-sen university of medical sciences
excellent teachig staff of guangdong provincial people's hospital
Pediatric critical care medicine(PCCM)(Chinese edition), editorial board member
Chinese journal of applied clinical pediatrics, expert reviewer.
key editor of AClinical Guide to Epileptic Syndromes and their Treatment（the second edition）,Case study of drug use lawsuit beyond drug instructions
associate editor of Rural General Practice
Professional memberships:Standing committee member of pediatric intensive care physicians,Chinese medical doctor association;member of professional committee on critical respiratory and mechanical ventilation;member of the standing committee ofChina association for pediatric disaster & emergency rescue medicine;chairman of the committee on disaster prevention of China association for pediatric disaster & emergency rescue medicine;vice chairman of pediatric respiratory intervention committee of guangdong chest diseases society;vice chairman of pediatric critical care medicine committee of guangdong provincial health management society;member of the standing committee of pediatric critical care medicine branch of guangdong medical association;headof children's heart and circulation groupof pediatric critical care medicine branch of guangdong medical association;standing member of pediatric committee of guangdongmedical education association;member of youth committee of China association against epilepsy;standing member of pediatric neurology of guangdong provincial society for the prevention and treatment of brain development and encephalopathy;secretary general on committee of experts of critical illness in children of guangdong pharmaceutical association.
Publications:He published sixty-seven papers in English and Chinese,of which thirty papers as first or corresponding author, and fourteen articles are indexed in SCI (H-index:5). The paper “High-frequency Oscillatory Ventilation is an Effective Treatment for Severe Pediatric Acute Respiratory Distress Syndrome with Refractory Hypoxemia” was cited by Surviving Sepsis Campaign International Guidelines for the Management of SepticShock and Sepsis-Associated OrganDysfunction in Children(Pediatr Crit Care Med 2020;21:e52-e106). His main academic papers are as follows:
[1]Qiong-xiang,Zhai*;Yu-xiong,Guo;Yu-xinZhang;Zhi-hong,Chen;Jian,Ding; Juan,Gui;Ying,Hao.Correlation of brain cellglucose metabolism and patient's condition in children with epilepticencephalopathy.Neural Regeneration Research. 2011,6(32):2521-2526.
[2]Zhou-yang Lian#,Biao Huang*,Shao-ruHe,Chang-hongLiang,Yu-xiong Guo. Diffusion-weighted imaging in the diagnosis of enterovirus 71 encephalitis.Acta Radiol.2012,53(2):208-13.
[3]Chen,Zhihong#,Wang,Lingan,Wang,Chun,Qian,Zhai,Qiongxiang*,Guo,Yuxiong,Zhang,Yuxin.Mutational analysis of CHRNB2,CHRNA2 and CHRNA4 genes in Chinese population with autosomal dominant nocturnalfrontal lobe epile- psy.Int J Clin Exp Med.2015,8(6):9063-9070.
[4]Chen,Zhi-Hong#;Wang,Chun;Wang,Lin-Gan;Zhuo,Mu-Qing;Tang,Zhi-Hong; Zhai,Qiong-Xiang*.Chen,Qian,Guo,Yu-Xiong,Zhang,Yu-Xin.Analysis of the CHRNA7 gene mutation and polymorphism in Southern Han Chinese patients with nocturnal frontal epilepsy.Asian Pac J Trop Med,2015,8(4):330-333.
[5]Zhi-hong Chen#,Yu-Xiong Guo, Mu-qing Zhuo, Yu-xin Zhang, ChunWang, Lin-ganWang,Qiong-xiangZhai*.A novel ARSA gene mutation c.302delG ina Chinese patient with metachromatic leukodystrophy.International journal of experimental pathology. 2016, 9(2): 1800-1804.
[6]GuoYu-xiong#,Zhao-Ni wang#,Ya-Ting Li,LiPan,Li-Fen Yang,YanHu. Yue-YuSun,Liang-Ming Cai,Chen-Zhuang Gui*.High-frequency oscillatory ventilation is an effective treatment for severe pediatric acute respiratory distress syndrome with refractory hypoxemia.Therapeutics and Clinical Risk Management.2016:12 1563-1571.
[7]Ya-Ting Li#,Li-FenYang,Zhuang-GuiChen,Lipan,Meng-Qi Duan,Yan Hu,Cheng-bin Zhou,Yu-Xiong Guo*.ECMO as an effective rescue therapeutic forfulminant myocarditis complicated withrefractory cardiac arrest. Therapeutics and Clinical Risk Management.2017:13:1507-1511.
[8]Ya-Ting Li#,Yu-Xiong Guo#,Liang-MingCa,LiPan,Meng-Qi Duan,Li-Fen Yang,Yue-Yu Sun,Wei-Ping Tan,Zhuang-Gui Chen*.Methylprednisolone pulse therapy rescued life-threatening pulmonary hemorrhagedue to idiopathic pulmon- aryhemosiderosis.American Journal of Emergency Medicine.2017,35(11):1786.e3-1786.e7.
[9]Zhi-Hong Chen#,ChunWang#,Mu-QingZhuo,Qiong-Xiang Zhai1,Qian Chen,Yu-XiongGuo,Yu-Xin Zhang,JuanGui,Zhi-Hong Tang*,Xiao-Lu Zeng.Exome sequencing identified a novel missense mutation c.464G>A (p.G155D) in Ca2+-binding protein4(CABP4) in a Chinese pedigree with autosomal dominant nocturnal frontal lobe epilepsy. Oncotarget.2017,8(45):78940-78947.
[10]Jian Ding#;Jing-Wen Zhang; Yu-Xiong Guo; Yu-Xin Zhang; Zhi-Hong Chen; =Qiong-Xiang Zhai*.Novel mutations in SCN9A occurring with fever-associated seizures or epilepsy.Seizure.2019,71:214-218.
[11]Guilang Zheng#,BangqinWang#,HuaZhang,ChuxingXie,Yuehua Zhang, ZhihongWen,QingyunGuo,HongZhu,GuojingYe,JiayiLiang,Qiong Meng,JingquanXie,SuhuaJiang,GuojunLiu,WenjunGao,YanhaoWang,Yuxiong Guo*.Clinicalcharacteristics of acute respiratory syndrome with SARS-CoV-2infection in children in South China.PediatricPulmonology.2020,55(9):2419-2416.
[12]Jian Ding#,Qin-Fei Miao,Jing-Wen Zhang,Yu-Xiong Guo,Yu-Xin Zhang,Qiong-Xiang Zhai,Zhi-Hong Chen*.H258R mutation in KCNAB3 gene in a family with genetic epilepsy and febrile seizures plus. Brain Behav.2020,10(12):e01859.
[13]Yu-Xiong Guo #,Hong-XiaMa # ,Yu-Xin Zhang,Zhi-Hong Chen,Qiong-Xiang Zhai*.Whole-exome sequencing for identifying genetic causes of intellectual developmental disorders.International Journal of General Medicine.Medicine.International Journal of General Medicine.2021:14:1275-1282.
[14]HongxiaMa#,Yu xiong Guo#,ZhihongChen,LinganWang,ZhihongTang, Jing wenZhang,QinfeiMiao,QiongxiangZhai*.Mutations in the sodium channel genes SCN1A,SCN3A,and SCN9A in children with epilepsy with febrile seizures plus(EFS+).Seizure.2021,88:146-152.
