个人简介

1996.09–2001.06 中山医科大学临床医学专业 本科

2007.09–2010.06 广东省心血管病研究所肿瘤学专业 硕士研究生（导师：吴一龙教授）

2010.07–2017.06 南方医科大学肿瘤学专业 博士研究生（导师：吴一龙教授）

2001.08–2007.11 广东省人民医院胸外科 住院医师

2007.12–2011.11 广东省人民医院胸外科 主治医师

2013.03–2014.06 哈佛大学医学院/麻省总医院 访问学者

2011.12–2021.01 广东省人民医院胸外科 副主任医师

2021.02–2022.02 江西省肿瘤医院 副院长（中组部挂职）

江西省肺癌研究所所长 行政主任

2022.05–2023.05 广东省人民医院教育处 副处长

2021.02–至今 广东省人民医院胸外科 主任医师

研究方向

胸部肿瘤（以肺癌、食管癌为主）机器人辅助及微单孔胸腔镜微创治疗与转化研究；肺癌围术期人工智能体系构建与个体化诊疗

代表性论著

[1] Lintong Yao#; Linghan Cai#; Maotao Weng#; Qiaxuan Li#; Fengchun Liu; Yingwei Lu; Jiawen Cui; Hongwei Lin; Henian Yao; Daipeng Xie; Shaowei Wu; Luyu Huang; Canjia Cai; Yu Lei; Ruihao Xie; Qi Zhang; Minjian Li; Weijie Zhan; Wenxin Zeng; Fanjun Zeng; Fasheng Li; Haihui Zhong; Zhu Liang; Jinchi Dai; Boyu Lin; Dongkun Zhang; Baozhen Zeng; Guangyi Wang; Lawrence Wing-Chi Chan; Launti Michael; Guibin Qiao; Cheng Lu; Zaiyi Liu; Qingling Zhang*; Yongbin Zhang*; Haiyu Zhou*. Deep Learning Model for Pathological Invasiveness Prediction Based on Surgical Resection Images Using Smartphone in Clinical Stage IA Lung Adenocarcinoma (SuRImage)：a Prospective, Multicentric Study. The Lancet Digital Health. 2026. Accepted. （1区，IF: 24.1）

[2] Bin Xu#, Fanjun Zeng#, Jialong Deng#, Lintong Yao, Shengbo Liu, Hengliang Hou, Yucheng Huang, Hongyuan Zhu, Shaowei Wu, Qiaxuan Li, Weijie Zhan, Hongrui Qiu, Huili Wang, Yundong Li, Xianzhu Yang, Ziyang Cao*, Yu Zhang*, Haiyu Zhou*. A homologous and molecular dual-targeted biomimetic nanocarrier for EGFR-related non-small cell lung cancer therapy. Bioactive Material. 2023;27:337-347.（1区，IF: 20.3）

[3] Haiyu Zhou#, Shaopeng Zheng#, Anlin Li#, Quan-Long Gao#, Qi-Yun Ou#, Yong-Jian Chen, Shao-Tao Wu, Da-Gui Lin, Sheng-Bo Liu, Lu-Yu Huang, Fa-Sheng Li, Hong-Yuan Zhu, Gui-Bin Qiao, Michael Lanuti*, He-Rui Yao*, Yun-Fang Yu*. Clinical evidence for association of neoadjuvant chemotherapy or chemoradiotherapy with efficacy and safety in patients with resectable esophageal carcinoma （NewEC study）. EClinicalMedicine. 2020; 24:100422.（1区，IF: 10）

[4] Bin Xu#, Hongrui Qiu#, Huili Wang#, Shengbo Liu, Hao Li, Shidang Xu, Lei Jiang, Hengliang Hou, Xingyang Zhao, Xin Li, Yucheng Huang, Yanjuan Gu*, Wing-tak Wong*, Shiying Li*, Haiyu Zhou*. Anti-Triggering Receptor Expressed on Myeloid Cells 2-Conjugated Nanovesicles Loaded Vadimezan Reprogram Tumor-Associated Macrophages to Combat Recurrent Lung Cancer. ACS Nano. 2025; 19(36):32674-32692. （1区，IF: 16）

[5] Benjamin Izar#, Haiyu Zhou#, Rebecca S. Heist, Christopher G. Azzoli, Alona Muzikansky, Emily E.F. Scribner, Lindsay A. Bernardo, Dora Dias-Santagata, Anthony J. Iafrate, Michael Lanuti*. The prognostic impact of KRAS, its codon and amino acid specific mutations, on survival in resected stage I lung adenocarcinoma. Journal of Thoracic Oncology. 2014;9(9):1363-9.（1区，IF: 20.8）

[6] Shaowei Wu#, Weijie Zhan#, Lan Liu#, Daipeng Xie, Lintong Yao, Henian Yao, Guoqing Liao, Luyu Huang, Yubo Zhou, Peimeng You, Zekai Huang, Qiaxuan Li, Bin Xu, Siyun Wang, Guangyi Wang, Dongkun Zhang, Guibin Qiao, Lawrence Wing-Chi Chan, Michael Lanuti, Haiyu Zhou*. Pretreatment radiomic biomarker for immunotherapy responder prediction in stage IB-IV NSCLC (LCDigital-IO Study): A multi-center retrospective study. Journal for ImmunoTherapy of Cancer. 2023 Oct;11(10):e007369.（1区，IF: 10.6）

[7] Jiahan Li, Yu Lei, Jiuyang Dong, Yongbing Zhang*, Haiyu Zhou*, Xiaopeng Fan. Context-Aware Contrastive Learning for Virtual IHC Staining With Inconsistent Image Pairs. IEEE Trans Image Process. 2025;34:7744-7758. （1区，IF: 13.7）

[8] Guanchao Ye#, Zhitao Wei#, Chu Han#, Guangyao Wu#, Chinting Wong#, Yanting Liang, Xiaobo Chen, Wang Zhou, Jianbo Gao, Changhong Liang, Yongde Liao, Lizza E.L. Hendriks, Leonard Wee, Dirk De Ruysscher, Andre Dekker, Haiyu Zhou*, Yu Qi*, Zaiyi Liu*, Zhenwei Shi*. AI-derived longitudinal and multi-dimensional CT classifier for non-small cell lung cancer to optimize neoadjuvant chemoimmunotherapy decision: a multicentre retrospective study. EClinicalMedicine. 2025; 89:103551.（1区，IF: 10）

[9] Yucheng Huang#, Miao Su#, Weihuan Lin#, Peirong Zhang, Hengliang Hou, Fanjun Zeng, Luyu Huang, Qiaxuan Li, Jialong Deng, Shengbo Liu, Hongrui Qiu, Xiaoqing Yuan, Li Peng*, Bin Xu*, Haiyu Zhou*. NIR-II light-driven in situ nanovaccine for cancer immunotherapy via lymph node migration-mediated accumulation. Theranostics. 2025; 15(15): 7677-7692. （1区，IF: 13.3）

[10] Bin Xu#, Hengliang Hou#, Weijia Xu#, Xiaoping Xie, Yucheng Huang, Fanjun Zeng, Weihuan Lin, Qiaxuan Li, Xiaoqiu Li*, Xianzhu Yang*, Haiyu Zhou*. An all-in-one polymeric nanomedicine as in situ cascade cancer vaccine for potent cancer immunotherapy. Nano Today 2025; 62: 102691.（1区，IF: 10.9）

[11] Xin Li#, Xuehan Wang#, Hongrui Qiu, Shiying Li, Lik Hang Hugo Tse, Wai-Sum Lo, Kwok-Ho Lui, Haiyu Zhou*, Yanjuan Gu*, Wing-tak Wong*. Engineering optimal gold nanorod-loaded hollow mesoporous organosilica nanotheranostics for NIR-II photoacoustic microscopy imaging and tumor synergistic therapy. Chemical Engineering Journal. 2024 Oct; 498:155310.（1区，IF: 13.2）

[12] Jingyi Wen, Lingxuan Zou, Jiying Liu, Xi Guo, Changkun Liu, Bensu Wang , Tongtong Deng, Chang Liu, Risheng Tang, Yanbin Yang , Yucheng Huang , Lijia Yang , Hui Wang , Zihao Li, Shengming Lin, Shipping Liu, Yuhu Zhang, Zhifeng Hao, Haiyu Zhou*, Han Huang*, Fei Ling*. PRTS: Predicting Single-Cell Spatial Transcriptomic Maps from Histological Images. Research (Wash D C). 2025 Nov 6;8:0961.（1区，IF: 10.9）

[13] Siqi Cai#, Yizhi Liao, Lixuan Lai, Haiyu Zhou*, Longhan Xie*. Automatic contour correction of pectus excavatum using computer-aided diagnosis and convolutional neural network. Engineering Applications of Artificial Intelligence. 2023;126, Part C, 107032.（2区，IF: 8）

[14] Luyu Huang#, Weihuan Lin#, Daipeng Xie, Yunfang Yu, Hanbo Cao, Guoqing Liao, Shaowei Wu, Lintong Yao, Zhaoyu Wang, Mei Wang, Siyun Wang, Guangyi Wang, Dongkun Zhang, Su Yao, Zifan He, William Chi‑Shing Cho, Duo Chen, Zhengjie Zhang, Wanshan Li, Guibin Qiao*, Lawrence Wing‑Chi Chan*, Haiyu Zhou*. Development and validation of a preoperative CT-based radiomic nomogram to predict pathology invasiveness in patients with a solitary pulmonary nodule: a machine learning approach, multicenter, diagnostic study. European Radiology. 2022;32（3）:1983-1996.（2区，IF: 4.7）

[15] Guoqing Liao#, Luyu Huang#, Shaowei Wu#, Peirong Zhang, Daipeng Xie, Lintong Yao, Zhengjie Zhang, Su Yao, Lyu Shanshan, Siyun Wang, Guangyi Wang, Lawrence Wing-Chi Chan*, Haiyu Zhou*. Preoperative CT-based Peritumoral and Tumoral Radiomic Features Prediction for Tumor Spread Through Air Spaces in Clinical Stage I Lung Adenocarcinoma. Lung Cancer. 2022;163:87-95.（2区，IF: 4.4）

代表性课题

1. 国家自然科学基金面上项目，2025.01-2028.12，48万元，在研，主持

2. 工信部人工智能医疗器械创新任务揭榜挂帅项目，2026.01-2028.12，在研，主持

3. 广东省自然科学基金面上项目，2024.01-2026.12，15万元，在研，主持

4. 广州地区临床重大技术建设项目，2026.01-2028.12，20万元，在研，主持

5. 广东省国际科技合作项目，2022.06-2025.7，50万元，结题，主持

6. 广东省自然科学基金面上项目，2021.01-2022.12，10万元，结题，主持

7. 广州市民生科技攻关计划，2019.01-2021.12，100万元，结题，主持

学术任职

1. 中国抗癌协会整合肿瘤相关结节专业委员会，副主任委员兼秘书长

2. 中国抗癌协会肿瘤人工智能专业委员会，常务委员

3. 中国抗癌协会小细胞肺癌专业委员会，常务委员

4. 中国肺癌AI及机器人技术转化研究协作组，组长

5. 广东省医师协会医学机器人医师分会，主任委员

6. 广东省健康管理学会胸部肿瘤及肺结节管理专业委员会，主任委员

7. 广州抗癌协会食管癌专委会，主任委员

8. 广东省肺部肿瘤精准治疗联盟，副主任委员

9. 美国胸外科医师协会(STS)国际关系部委员

执教课程（课程及教材建设）

1. 外科学

2. 肿瘤学

荣誉奖励

1. 广东省科学技术奖科技进步奖，二等奖，2024

2. 中国抗癌协会科技奖，二等奖，2024

3. 广东省杰出青年医学人才，2017