个人简介

教育背景：

2009-2012，日本新潟大学,自然科学研究科，博士

2006-2009，鲁东大学，生命科学学院，硕士

2002-2006，内蒙古大学，生命科学学院，学士

工作经历：

2021-至今，广东省人民医院，博导

2018-2021，华南理工大学，特聘副研究员，硕导

2017-2018，中国科技大学,生命科学学院，特聘副研究员

2012-2016，中国科技大学,生命科学学院，博士后

研究方向

肿瘤代谢与肿瘤免疫

代表性论著

1. Liu S#, Cai J#, Qian X, Zhang J, Zhang Y, Meng X, Wang M, Gao P*, Zhong X*. (2025) TPX2 lactylation is required for the cell cycle regulation and hepatocellular carcinoma progression. Life Science Alliance. 8(6):e202402978.

2. Qian X#, Cai J#, Zhang Y, Shen S, Wang M, Liu S, Meng X, Zhang J, Ye Z, Qiu S, Zhong X*, Gao P*. (2024) EPDR1 promotes PD-L1 expression and tumor immune evasion by inhibiting TRIM21-dependent ubiquitylation of IkappaB kinase-β. The EMBO Journal. 43(19):4248-4273.

3. Zhang Y#, Wang M#, Ye L#, Shen S, Zhang Y, Qian X, Zhang T, Yuan M, Ye Z, Cai J, Meng X, Qiu S, Liu S, Liu R, Jia W, Yang X*, Zhang H*, Zhong X*, Gao P*. (2024) HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression. Nature Communications.15(1):1314.

4. Qiu S#, Zhong X#*, Meng X#, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H*, Gao P*. (2023) Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression. Cell Research. 33(4):299-311.

5. Wei H#, Ma W#, Lu X, Liu H, Lin K, Sun L, Huang Z, Cheng EY., Zhang H, Gao P*, Zhong X*. (2021) KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression. Cancer Communications. 41(9):904-920.

6. Wang Y#, Lu H#, Sun L, Chen X, Wei H, Suo C, Feng J, Yuan M, Shen S, Jia W, Wang Y, Zhang H*, Li Z*, Zhong X*, Gao P*. (2021) Metformin sensitizes hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase. Cell Death & Disease. 12: 902.

7. Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q and Gao P. (2019) Mitochondrial dynamics is critical for the full pluripotency and embryonic developmental potential of pluripotent stem cells. Cell Metabolism. 29(4):979-992.e4.

8. Tian S#, Feng J#, Cao Y, Shen S, Cai Y, Yang D, Yan R, Wang L, Zhang H, Zhong X*, and Gao P*. (2019) Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications. Life Science Alliance. 2(5). pii: e201900413.

9. Zhong X#, Tian S#, Zhang X, Diao X, Dong F, Yang J, Li Z, Sun L, Wang L, He X, Wu G, Hu X, Wang L, Song L, Zhang H, Pan X, Li A*, and Gao P*. (2017) CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis. EMBO Reports. 18(5):809-825.

10. Yan R, Zhang P, Shen S, Zeng Y, Wang T, Chen Z, Ma W, Feng J, Suo C, Zhang T, Wei H, Jiang Z, Chen R, Li ST, Zhong X, Jia W, Sun L, Cang C, Zhang H, Gao P. (2024) Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion. Nature Immunology. 25(3):483-495.

代表性课题

1. 国家自然科学基金面上项目，2026.1-2029.12，50万元，在研，主持

2. 国家自然科学基金青年科学基金B类（原优秀青年科学基金），2024.01-2026.12，200万元，在研，主持

3. 国家自然科学基金面上项目，2021.1-2024.12，55万元，结题，主持

4. 国家自然科学基金青年基金C类，2018.1-2020.12，26万元，结题，主持

5. 广州市基础研究计划市校（院）企联合资助专题项目，2025.01-2027.12，250万元，在研，主持

学术任职

中国抗癌协会肿瘤转移专业委员会，委员