个人简介

2011年美国宾州州立大学获生物信息学博士，曾在美国哥伦比亚大学和NIH疫苗研究中心任博士后研究员近三年。2014年获中组部海外高层次引进人才称号，中国生物工程学会生物信息分会副主任委员。归国以来致力于免疫组库测序技术开发及其在自身免疫疾病、肿瘤、大健康领域的科研及应用。以重要作者身份在Science和Cell等国际期刊发文60余篇，总影响因子逾700，总引用次数6000余次。

经历

1995.09--1999.07 北京航空航天大学计算机科学与工程系本科

1999.08—2002.01 北京深思软件股份有限公司软件开发部工程师

2002.02--2007.07 新加坡分子细胞生物研究所斑马鱼研究中心

2007.08--2011.02 美国宾州州立大学集成生物学系博士

2011.03--2013.06 美国国立卫生院疫苗研究中心

2013.7--2020.11 南方医科大学南方医院肾内科教授

2020.11--至今 广东省人民医院医学研究部教授

研究方向

免疫组库测序技术开发及其在自身免疫疾病、肿瘤、大健康领域的科研及应用

代表性论著

1. Zhu Y., Tang H., Xie W., Chen S., Zeng H., Lan C., Guan J., Ma C., Yang X., Wang Q., Wei L., Zhang Z., Yu X., The multilevel extensive diversity across the cynomolgus macaque captured by ultra-deep adaptive immune receptor repertoire sequencing, Sci Adv, 2024, 10(4): eadj5640

2. Chen Yuan, Ye Zhiming, Zhang Yanfang, Xie Wenxi, Chen Qingyun, Lan Chunhong, Yang Xiujia, Zeng Huikun, Zhu Yan, Ma Cuiyu, Tang Haipei, Wang Qilong, Guan Junjie, Chen Sen, Li Fenxiang, Yang Wei, Yan Huacheng, Yu Xueqing, Zhang Zhenhai, A Deep Learning Model for Accurate Diagnosis of Infection Using Antibody Repertoires, Journal of Immunology, 2022, 208(12): 2675-2685

3. Yang Xiujia, Wang Minhui, Wu Jiaqi, Shi Dianchun, Zhang Yanfang, Zeng Huikun, Zhu Yan, Lan Chunhong, Deng Yang, Guo Shixin, Xu Lijun, Ma Cuiyu, Zhang Yanxia, Ou Jinxia, Liu Chu-Jun, Chen Yuan, Wang Qilong, Xie Wenxi, Guan Junjie, Ding Jieyu, Wang Zhi, Chang Changqing, Yang Wei, Zhang Huijie, Chen Jun, Qin Lijie, Zhou Hongwei, Bei Jin-Xin, Wei Lai, Cao Guangwen, Yu Xueqing, Zhang Zhenhai, Large-scale analysis of 2,152 Ig-seq datasets reveals key features of B cell biology and the antibody repertoire, Cell Reports, 2021, 35(6): 109110

4. Zhu Yan, Yang Xiujia, Ma Cuiyu, Tang Haipei, Wang Qilong, Guan Junjie, Xie Wenxi, Chen Sen, Chen Yuan, Wang Minhui, Lan Chunhong, Sun Deqiang, Wei Lai, Sun Caijun, Yu Xueqing, Zhang Zhenhai, Antibody upstream sequence diversity and its biological implications revealed by repertoire sequencing, Journal of Genetics and Genomics, 2021, 48(10): 936-945

5. Zhang Yanfang, Chen Tianjian, Zeng Huikun, Yang Xiujia, Xu Qingxian, Zhang Yanxia, Chen Yuan, Wang Minhui, Zhu Yan, Lan Chunhong, Wang Qilong, Tang Haipei, Zhang Yan, Wang Chengrui, Xie Wenxi, Ma Cuiyu, Guan Junjie, Guo Shixin, Chen Sen, Yang Wei, Wei Lai, Ren Jian, Yu Xueqing, Zhang Zhenhai, RAPID: A Rep-Seq Dataset Analysis Platform With an Integrated Antibody Database, Frontiers in Immunology, 2021, 12: 717496

6. Wang Qilong, Zeng Huikun, Zhu Yan, Wang Minhui, Zhang Yanfang, Yang Xiujia, Tang Haipei, Li Hongliang, Chen Yuan, Ma Cuiyu, Lan Chunhong, Liu Bin, Yang Wei, Yu Xueqing, Zhang Zhenhai, Dual UMIs and Dual Barcodes With Minimal PCR Amplification Removes Artifacts and Acquires Accurate Antibody Repertoire, Frontiers in Immunology, 2021, 12: 778298

7. Zhang Yanfang, Yang Xiujia, Zhang Yanxia, Zhang Yan, Wang Minhui, Ou Jin Xia, Zhu Yan, Zeng Huikun, Wu Jiaqi, Lan Chunhong, Zhou Hong-Wei, Yang Wei, Zhang Zhenhai, Tools for fundamental analysis functions of TCR repertoires: a systematic comparison, Briefings in Bioinformatics, 2020, 21(5): 1706-1716

8. Sun J., Zhang Y., Wang M., Guan Q., Yang X., Ou J. X., Yan M., Wang C., Zhang Y., Li Z. H., Lan C., Mao C., Zhou H. W., Hao B., Zhang Z., The Biological Significance of Multi-copy Regions and Their Impact on Variant Discovery, Genomics Proteomics Bioinformatics, 2020, 18(5): 516-524

9. Wu X., Zhang Z., Schramm C. A., Joyce M. G., Kwon Y. D., Zhou T., Sheng Z., Zhang B., O'Dell S., McKee K., Georgiev I. S., Chuang G. Y., Longo N. S., Lynch R. M., Saunders K. O., Soto C., Srivatsan S., Yang Y., Bailer R. T., Louder M. K., Program Nisc Comparative Sequencing, Mullikin J. C., Connors M., Kwong P. D., Mascola J. R., Shapiro L., Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection, Cell, 2015, 161(3): 470-485

10. Zhang Z., Wippo C. J., Wal M., Ward E., Korber P., Pugh B. F., A packing mechanism for nucleosome organization reconstituted across a eukaryotic genome, Science, 2011, 332(6032): 977-80

代表性课题

1. 国家自然科学基金面上项目，2024.01-2027.12，50万元，在研，主持

2. 广东省基础与应用基础研究基金，2022.11-2025.10，100万元，结题，主持

3. 国家重点研发计划子课题，2022.11-2025.10，150万元，结题，主持

4. 国家自然科学基金面上项目，2018.01-2021.12，60万元，结题，主持

学术任职

1. 中国生物工程学会生物信息分会，副主任委员

2. 广东省生物信息学会，副理事长

3. 广东省青年科学家协会，常务理事

执教课程（课程及教材建设）

1. 高通量测序技术及应用

荣誉奖励

1. 国家海外引进青年，2014

2. 广东省五四青年奖章，2014