个人简介

2007.09-2014.11，哈尔滨⼯业⼤学，计算机应⽤技术（生物信息），博⼠

2005.09-2014/09，哈尔滨医科⼤学，⽣物信息科学与技术学院，助教/讲师

2015/09-2016/11，Haukeland University Hospital, Bergen, Norway，Mohn Cancer Research Laboratory (博⼠后合作导师:Per Eystein Lønning, Stian Knappskog)

2017/06-2020/08，MD Anderson cancer center, Houston, USA, Genomic Medicine，B-Cell Lymphoma Moon Shot (博⼠后合作导师:Linghua Wang; Luhua Michael Wang) Melanoma Moon Shot (博⼠后合作导师:Linghua Wang; Jennifer Wargo)

2020.12-⾄今，⼴东省⼈民医院医学研究部，副研究员

研究方向

（1）单细胞空间转录组，表观组等临床样本数据整合分析；（2）高精度空间转录组相关技术开发；（3）癌症基因组癌症克隆异质性算法开发；（4）超高通量单细胞测序技术开发；

代表性论著

1. Shaojun Zhang*, Changying Jiang*, Yuanxin Wang, Rongjia Zhang, Yang Liu, Joseph McIntosh, Guangchun Han, Ruiping Wang, David Santos, Maria Badillo, Angela Leeming, Zhihong Chen, Kimberly Hartig, John Bigcal, Hun Lee, Raphael Steiner, Jorge Romaguera, Preetesh Jain, Krystle Nomie, Andrew Futreal1, Linghua Wang† & Michael Wang†: Longitudinal Single-Cell Transcriptome Profiling Reveals Clonal Evolution and Strategies to Overcome Therapeutic Resistance in Mantle Cell Lymphoma. Nature Communication. 2021 May;  (Co-first author)

2. Beth A. Helmink*, Sangeetha M. Reddy*, Jianjun Gao*, Shaojun Zhang*, Rafet Basar, Rohit Thakur, Keren Yizhak, Moshe Sade-Feldman, Jorge Blando, Guangchun Han, Vancheswaran Gopalakrishnan, Yuanxin Xi, Hao Zhao, Rodabe N. Amaria, Hussein A. Tawbi, Alex P. Cogdill, Wenbin Liu, Valerie S. LeBleu, Fernanda G. Kugeratski, Sapna Patel, Michael A. Davies, Patrick Hwu, Jeffrey E. Lee, Jeffrey E. Gershenwald, Anthony Lucci, Reetakshi Arora, Scott Woodman, Emily Z. Keung, Pierre-Olivier Gaudreau, Alexandre Reuben, Christine N. Spencer, Elizabeth M. Burton, Lauren E. Haydu, Alexander J. Lazar, Roberta Zapassodi, Courtney W. Hudgens, Deborah A. Ledesma, SuFey Ong, Michael Bailey, Sarah Warren, Disha Rao, Oscar Krijgsman, Elisa A. Rozeman, Daniel Peeper, Christian U. Blank, Ton N. Schumacher, Lisa H. Butterfield, Monika A. Zelazowska, Kevin M. McBride, Raghu Kalluri, James Allison, Florent Petitprez, Wolf Herman Fridman, Catherine Sautès-Fridman, Nir Hacohen, Katayoun Rezvani, Padmanee Sharma, Michael T. Tetzlaff, Linghua Wang & Jennifer A. Wargo†: B-cell and tertiary lymphoid structures predict immune checkpoint blockade response. Nature. 2020 Jan;577(7791):549-555. (Co-first author)

3. Liang Zhang*, Yixin Yao*, Shaojun Zhang*, Yang Liu, Hui Guo, Makhdum Ahmed, Taylor Bell, Hui Zhang, Guangchun Han, Elizabeth Lorence, Maria Badillo, Shouhao Zhou, Yuting Sun, M. Emilia Di Francesco, Ningping Feng, Randy Haun, Renny Lan, Samuel G.Mackintosh, Xizeng Mao, Xingzhi Song, Jianhua Zhang, Lan V. Pham, Philip L. Lorenzi, Joseph Marszalek, Tim Heffernan, Giulio Draetta, Philip Jones, Andrew Futreal, Krystle Nomie, Linghua Wang† & Michael Wang†: Metabolic reprogramming towards OXPHOS identifies a novel therapeutic target for mantle cell lymphoma. Sci Transl Med. 2019 May 8;11(491) (Co-first author)

4. Fang Wang, Shaojun Zhang, Tae-Beom Kim, Yu-yu Lin, Ramiz Iqbal, Zixing Wang, Vakul Mohanty, Kanishka Sircar, Jose A. Karam, Michael C. Wendl, Funda Meric- Bernstam, John N. Weinstein, Li Ding, Gordon B. Mills & Ken Chen†. Integrated transcriptomic–genomic tool Texomer profiles cancer tissues. Nature Methods. 2019 May; 16(5):401-404.

5. Edoardo Del Poggetto, I-Lin Ho, Chiara Balestrieri, Er-Yen Yen, Shaojun Zhang, Francesca Citron, Rutvi Shah, Denise Corti, Giuseppe R. Diaferia, Chieh-Yuan Li, Sara Loponte, Federica Carbone, Yoku Hayakawa, Giovanni Valenti, Shan Jiang, Luigi Sapio, Hong Jiang, Prasenjit Dey, Sisi Gao, Angela K. Deem, Stefan Rose-John, Wantong Yao, Haoqiang Ying, Andrew D. Rhim, Giannicola Genovese, Timothy P. Heffernan, Anirban Maitra, Timothy C. Wang, Linghua Wang, Giulio F. Draetta, Alessandro Carugo, Gioacchino Natoli, Andrea Viale†. Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis. Science, 2021; 373 (6561) DOI: 10.1126/science.abj0486

6. E. Birkeland, Shaojun Zhang, D. Poduval, J. Geisler, S. Nakken, D. Vodak, L. A. Meza- Zepeda, E. Hovig, O. Myklebost, S. Knappskog† & P. E. Lønning†. Patterns of genomic evolution in advanced melanoma. Nature Communications. 2018 Jul 10 [PMID: 6039447]

7. Shaojun Zhang, Xu Liangde, Wang Fang, Wang Hongzhi, Gong Binsheng, Zhang Fan, Li Xia, Wang Yadong: Genetic control of primary microRNA insight into cis- and trans- regulatory variations by RNA-seq. Gene, 2013. 517(2): p. 224-9. [PMID: 23291411]

8. Yuchao He, Linlin Zhan, Jian Shi, Manyu Xiao, Ran Zuo, Chengmeng Wang, Zhiyong Liu, Wenchen Gong, Liwei Chen, Yi Luo, Shaojun Zhang, Youwei Wang, Lu Chen, Hua Guo：The Combination of R848 with Sorafenib Enhances Antitumor Effects by Reprogramming the Tumor Immune Microenvironment and Facilitating Vascular Normalization in Hepatocellular Carcinoma, Adv Sci (Weinh). (2023), vol. 10, pp. e2207650.

9. Ying Wang, Min Zhang, Jian Shi, Yue Zhu, Xin Wang, Shaojun Zhang†, Fang Wang†: Cracking the pattern of tumor evolution based on single-cell copy number alterations. Briefings in Bioinformatics, Volume 24, Issue 6, November 2023, bbad341

10. Xin Wang , Min Zhang , Hang Li , Yuhao Deng , Ying Wang , Yanru Zhang , Hongjiu Wang , Zhenzhen Wang , Fang Wang , Shaojun Zhang†: ChromoPattern: characterizing chromosomal rearrangement patterns of copy number alteration in heterogeneous tumor cell populations at single-cell resolution Open Access. Briefings in Bioinformatics, Volume 26, Issue 5, September 2025, bbaf563

代表性课题

1. 基于⾼通量测序技术转录后调控复杂性进化模型及平台的构建 (国家⾃然科学基⾦青年项⽬，2015，主持)

2. 基于新⼀代测序技术的转录后调控复杂性进化研究 (⿊龙江省⾃然科学基, 2014，主持)

3. 单细胞多维数据解析拷贝数变异驱动的肿瘤耐药基因调控机制 (国家⾃然科学基⾦⾯上项⽬，2021，主持)

4. 多组学整合探索肿瘤拷贝数克隆的空间演化模式 (国家⾃然科学基⾦⾯上项⽬，2026，主持)

学术任职

1. 中国抗癌协会肿瘤标志物专业委员会，委员

执教课程（课程及教材建设）

《生物信息学》，《基因组信息学》,《分子进化分析》,《UNIX操作系统》，《医用高等数学》,  哈尔滨医科大学 ,  2005-2015