个人简介

1997-09--2002-06 中山大学临床医学专业本科

2002-09--2004-06 中山大学临床医学专业硕士研究生

2004-09--2007-06 中山大学肿瘤学专业博士研究生

2007-07--2010-11, 广东省人民医院乳腺科医师

2010-12--2013-11, 广东省人民医院乳腺科主治医师

2013-12--今, 广东省人民医院乳腺科副主任医师

研究方向

乳腺癌临床转化研究与靶向治疗

代表性论著

1. Guochun Zhang#, Chongyang Ren#, Cheukfai Li#, Yulei Wang, Bo Chen, Lingzhu Wen, Minghan Jia, Kai Li, Hsiaopei Mok, Li Cao, Xiaoqing Chen, Jiali Lin, Guangnan Wei, Yingzhi Li, Yuchen Zhang, Charles M. Balch, Ning Liao*. Distinct clinical and somatic mutational features of breast tumors with high-, low-, or non-expressing human epidermal growth factor receptor 2 status, BMC Medicine, 2022, 20(1):142

2. Bo Chen#, Guochun Zhang#, Jianguo Lai#, Weikai Xiao#, Xuerui Li, Cheukfai Li, Hsiaopei Mok, Kai Li, Yulei Wang, Li Cao, Minghan Jia, Chongyang Ren, Lingzhu Wen, Guangnan Wei, Jiali Lin, Yingzi Li, Yuchen Zhang, Xiaoqing Chen, Xueying Wu, Henghui Zhang, Min Li, Jing Liu, Charles M. Balch, Ning Liao*. Genetic and immune characteristics of sentinel lymph node metastases and multiple lymph node metastases compared to their matched primary breast tumours, EBioMedicine, 2021, 71: 103542

3. Yulei Wang*, Lingzhu Wen, Xiaoqing Chen, Guangnan Wei, Guosong Jiang, Guochun Zhang*. Selenium-binding protein 1 transcriptionally activates p21 expression via p53-independent mechanism and its frequent reduction associates with poor prognosis in bladder cancer, Journal of Translational Medicine, 2020, 18(1): 17

4. Xiaoyi Lin#, Lijuan Guo#, Xin Lin#, Yulei Wang, Guochun Zhang*. Concomitant PIK3CA and TP53 Mutations in Breast Cancer: An Analysis of Clinicopathologic and Mutational Features, Neoadjuvant Therapeutic Response, and Prognosis, Journal of breast cancer, 2023, 26(4): 363-377

5. Hsiao-Pei Mok#, Lingzhu Wen#, Xiaoyi Lin, Xin Lin, Ning Liao, Guochun Zhang*. Submuscular Implant-Based Breast Reconstruction Using a Musculofascial Pocket Formed by the Pectoralis Major Muscle and the Serratus Anterior Muscle Fascia: A Novel Surgical Approach, World Journal of Surgery, 2022, 46: 1451-1456

6. Yingying Qian#, Miao Zhu#, Chongyang Ren#, Yeyong Zhou, Jian Xu, Liang Dong, Guangyu Zhang, Cheukfai Li, Jiaoyi Lv , Qiaorui Xing, Guochun Zhang*, Guangdun Peng*, Ning Liao*. Spatial Chromatin Accessibility Analysis of Intratumor Heterogeneity in Breast Cancer, Genomics, Proteomics & Bioinformatics, 2026, 12:qzag001.

7. Yulei Wang*#, Wenhang Lin#, Yixuan Liao, Guochun Zhang*, Selenium-binding protein 1 suppresses tumor invasion by destabilizing MMP2 mRNA through a p21-dependent AUF1-ARE regulatory axis, Biochemical and Biophysical Research Communications, 2025, 787(1): 152794

代表性课题

1. 广东省自然科学基金面上项目，2024.01-2026.12，15万元，在研，主持

2. 国家自然科学基金面上项目，2023.01-2026.12，52万元，在研，参与

学术任职

1. 广东省中西医结合学会乳腺癌专业委员会，副主任委员

2. 中国抗癌协会肿瘤转移专业委员会，委员

3. 中华医学会肿瘤学分会乳腺肿瘤青年学组，委员

4. 中国抗癌协会乳腺癌专业委员青委会，委员

5. 中国医师协会外科分会乳腺外科委员会青委会，委员

6. 广东省医师协会乳腺专科医师分会外科青年学组，副组长

7. 广东省胸部肿瘤防治研究会乳腺癌专业委员会，常委

8. 广东省抗癌协会乳腺癌专业委员会，委员