个人简介

1991.09 -1996.07 同济医科大学临床医学本科

1996.09–2001.07 华中科技大学同济医学院博士研究生

2004.12–2007.01 德国柏林心脏中心访问学者

2001.07–2010.10 同济医学院附属协和医院心外科主治医师

2010.11–2016.05 同济医学院附属协和医院心外科副主任医师

2016.05–2019.10 广东省人民医院心脏大血管外科副主任医师

2019.11–至今 广东省人民医院心脏大血管外科主任医师，行政科主任

研究方向

1、主动脉外科治疗：保主动脉根置换、复杂主动脉弓手术（冰冻象鼻）、胸腹主动脉瘤（TAAA）手术。

2、冠状动脉旁路移植术（CABG），尤其是冠状动脉内膜剥脱术。

3、二尖瓣、三尖瓣及主动脉瓣修复及置换术。

4、心血管疾病风险分层与手术质量评估。

代表性论著

1. Yanping Guo, Runze Tian, Zerui Chen, Yuhong Wang, Changjiang Yu, Nanbo Liu, Tucheng Sun, Shuoji Zhu, Tingting Liu, Bin Yao, Ping Zhu. 3D bioprinting hydrogel models of neurovascular unit for in vitro diabetic peripheral neuropathy study. J Biomater Sci Polym Ed. 2025 Jul 2:1-20.

2. Jinxing Peng, Zhuohang Jiang, Jiayu Song, Jinze Chen, Ziyun Fu, Huizhe Zhang, Jianfan Zhen, Muhetaijiang Tuerdi, Mingyang Luo, Jinlin Wu, Tucheng Sun*. Identification of lactylation-related hub genes as novel therapeutic and diagnostic targets for thoracic aortic dissection. Cell Signal. 2025 Oct;134:111944.

3. Mengmeng Wang, Bowei Li, Shuke Nie, Xin Meng, Guangxing Wang, Menghan Yang, Wenxin Dang, Kangning He, Tucheng Sun, Ping Xu, Xifei Yang, Keqiang Ye. Asparagine endopeptidase cleaves apolipoprotein A1 and accelerates pathogenesis of atherosclerosis. J Clin Invest. 2025 May 15;135(10):e185128.

4. Jizhong Wang , Jitao Liu, Fan Yang, Yinghao Sun, Jiaohua Chen, Jie Liu, Tucheng Sun, Ruixin Fan, Fang Pei, Songyuan Luo, Jie Li, Jianfang Luo. GMRSP encoded by lncRNA H19 regulates metabolic reprogramming and alleviates aortic dissection. Nat Commun. 2025 Feb 18;16(1):1719.

5. Jianfan Zhen, Xiang Luo, Jie Liu, Zerui Chen, Jinlin Wu, Tucheng Sun*. Impact of Warfarin and Dual Antiplatelet Therapy on Graft Failure After Coronary Endarterectomy: A Retrospective Cohort Study. Cardiovasc Drugs Ther. 2025 Jan 14.

6. Guang Tong, Shuang Zhao, Jinlin Wu, Zhongchan Sun, Donglin Zhuang, Zerui Chen, Yaorong Liu, Yongchao Yang, Ruixin Fan, Tucheng Sun*. Right axillary artery cannulation in acute type A aortic dissection with involvement of the right axillary artery. The Journal of Thoracic and Cardiovascular Surgery. 2024 Jul;168(1):50-59.e6.

7. Zhichao Wu, Jialiang Liang, Shuoji Zhu, Nanbo Liu, Mingyi Zhao, Fei Xiao, Guanhua Li, Changjiang Yu, Chengyu Jin, Jinshan Ma, Tucheng Sun*, Ping Zhu*. Single-cell analysis of graft-infiltrating host cells identifies caspase-1 as a potential therapeutic target for heart transplant rejection. Front Immunol. 2023 Sep 13;14:1251028.

8. Yuxiao Zhang#, Xiaoran Huang#, Tucheng Sun#, Linli Shi, Baojuan Liu, Yimei Hong, Qing-Ling Fu, Yuelin Zhang, Xin Li. MicroRNA-19b-3p dysfunction of mesenchymal stem cell-derived exosomes from patients with abdominal aortic aneurysm impairs therapeutic efficacy. J Nanobiotechnol. 2023 Apr 26;21(1):135.

9. Jinlin Wu, Yanfen Wu, Fei Li, Donglin Zhuang, Yunging Cheng, Zerui Chen, Jue Yang, Jie Liu, Xin Li, Ruixin Fan, Tucheng Sun*. Natural history of isolated abdominal aortic dissection: A prospective cohort study. Front Cardiovasc Med. 2023 Feb 23;10:1002832.

10. Jiade Zhu, Guang Tong, Donglin Zhuang, Yongchao Yang, Zhichao Liang, Yaorong Liu, Changjiang Yu, Zhen Zhang, Zerui Chen, Jie Liu, Jue Yang, Xin Li, Ruixin Fan, Tucheng Sun*, Jinlin Wu*. Surgical treatment strategies for patients with type A aortic dissection involving arch anomalies. Front Cardiovasc Med. 2022 Sep 13;9:979431.

11. Guang Tong, Jinlin Wu, Zerui Chen, Donglin Zhuang, Shuang Zhao, Yaorong Liu, Yongchao Yang, Zhichao Liang, Ruixin Fan, Zhongchan Sun, Tucheng Sun*. Coronary Malperfusion Secondary to Acute Type A Aortic Dissection: Surgical Management Based on a Modified Neri Classification. J Clin Med. 2022 Mar 18;11(6):1693.

12. Guang Tong, Zhongchan Sun, Jinlin Wu, Shuang Zhao, Zerui Chen, Donglin Zhuang, Yaorong Liu, Yongchao Yang, Zhichao Liang, Ruixin Fan, Tucheng Sun*. Aortic Balloon Occlusion Technique Does Not Improve Peri-operative Outcomes for Acute Type A Acute Aortic Dissection Patients With Lower Body Malperfusion. Front Cardiovasc Med. 2022 Mar 11;9:835896.

13. Shuoji Zhu, Changjiang Yu, Nanbo Liu, Mingyi Zhao, Zerui Chen, Jian Liu, Ge Li, Huanlei Huang, Huiming Guo, Tucheng Sun*, Jimei Chen*, Jian Zhuang*, Ping Zhu*. Injectable conductive gelatin methacrylate/oxidized dextran hydrogel encapsulating umbilical cord mesenchymal stem cells for myocardial infarction treatment. Bioact Mater. 2021 Nov 17;13:119-134.

14. Xianwu Zhou, Zerui Chen, Jianrong Zhou, Yaorong Liu, Ruixin Fan, Tucheng Sun*. Transcriptome and N6-Methyladenosine RNA Methylome Analyses in Aortic Dissection and Normal Human Aorta. Front Cardiovasc Med. 2021 May 28;8:627380.

15. Ying Li, Miaoxian Fang, Jue Yang, Changjiang Yu, Juntao Kuang, Tucheng Sun*, Ruixin Fan*. Analysis of the contribution of 129 candidate genes to thoracic aortic aneurysm or dissection of a mixed cohort of sporadic and familial cases in South China. Am J Transl Res. 2021 May 15;13(5):4281-4295.

16. Guang Tong, Donglin Zhuang, Zhongchan Sun, Zerui Chen, Ruixin Fan, Tucheng Sun*. Femoral artery cannulation as a safe alternative for aortic dissection arch repair in the era of axillary artery cannulation. J Thorac Dis. 2021 Feb;13(2):671-680.

17. Xianwu Zhou, Jiancheng Cheng, Zerui Chen, Huadong Li, Shu Chen, Fei Xu, Ruixin Fan, Jian Zhuang, Tucheng Sun*. Role of c-Abl in Ang I-induced aortic dissection formation: Potential regulatory efficacy on phenotypic transformation and apoptosis of VSMCs. Life Sciences. 2020 Sep 1;256:117882.

18. Jie He, Tucheng Sun(#), Zhengbo Chen, Dong Luo,  Sanming Wang, Gang Zhao(*). Surgical repair of aortic rupture  caused by retained neurointerventional guidewire. Ann Thorac Surg 2019;108:e81-4

19. Jiancheng cheng, Xianwu Zhou, Xionggang Jiang, Tucheng Sun*, Deletion of ACTA2 in mice promotes angiotensin II induced pathogenesis of thoracic aortic aneurysms and dissections. J Thorac Dis 2018; 10(8): 4733-4740

20. Tucheng Sun, Shu Chen, Nianguo Dong, Xianwu Zhou, Huadong Li. Imatinib inhibits angiotensin II- induced aortic dissection through the c-Abl signaling pathway. Int J Clin Exp Pathol  2017; 10(5): 5316-5324

21. Ke, Tie(#)，Han, Meng，Zhao, Miao，Wang, Qing Kenneth，Zhang, Huazhi，Zhao, Yuanyuan，Ruan, Xinlong，Li, Hui，Xu, Chengqi，Sun, Tucheng(*)，Alpha-actin-2 mutations in Chinese patients with a non-syndromatic thoracic aortic aneurysm. BMC Medical Genetics 2016.7.18，17（1）：45~53

22. Huadong Li, Xionggang Jiang, Tucheng Sun*. Open surgery for superior vena cava syndrome after failed endovascular stenting. Ann Thorac Surg 2014; 97(4): 1445-7

23. Huadong Li, Tucheng Sun*.Bowel ischemia caused by a giant thrombus in the ascending aorta: A case report. Vascular 2014; 23(6):641-4.

24. Tucheng Sun, Lin He, Zongquan Sun*. Damus-Kaye-Stansel Biventricular Repair for Transposition of the Great Arteries with Pulmonary Hypertension. J Card Surg 2010; 25(6): 742-744

25. Tucheng Sun, Gang Wang, Kailun Zhang, Huimin Liang, Xionggang Jiang*. Hybrid Procedure for Thoracic Aortic Disease. J Huazhong Univ Sci Technol. Med Sci. 2010; 30(5):666-668

26. Tucheng Sun, Xionggang Jiang, Kailun Zhang, Jie Cai, Shu Chen, NYANGASSA BJ, Zongquan Sun. Surgical Treatment of Aortic Aneurysm and Aortic Dissection：A Retrospective Analysis of 122 Cases. J Huazhong Univ Sci Technol. Med Sci.  2009; 29(2): 207-211

代表性课题

1. 广州地区临床重大技术项目，2026.01-2028.12，20万元，在研，主持

2. 国家“科技创新”2030 重大项目，2024.08-2028.07，515万，在研，主持

3. 国家自然科学基金面上项目，2024.01-2027.12，47万，在研，主持

4. 广州市科技局重点项目，2020.04-2023.03，100万，结题，主持

5. 国家自然科学基金面上项目，2014.01-2017.12，75万，结题，主持

6. 国家科技支撑计划，2012.01-2015.12，439万，结题，参与

学术任职

1. 中国教育协会心脏外科专业委员会，副主任委员

2. 广东省医师协会血管病分会，副主任委员

3. 广东省医学会心血管外科分会，常务委员

4. 广东省基层医药学会大血管专委会，主任委员

5. 广东省精准医学应用学会心脏大血管疾病分会，主任委员

6. 广东省生物医学工程学会胸心血管外科分会，常务委员

执教课程（课程及教材建设）

1. 本科选修课《柳叶刀的温度》

2. 《主动脉外科学（Surgery of the Aorta and lts Body Branches）》主译：孙图成，董念国

荣誉奖励

1. 广州好医护之广州名医，广州市卫生健康委员会，2025

2. 医学科技奖励“临床医学创新奖”二等奖，中国研究型医院学会，2024

3. 广东省科技进步一等奖，广东省人民政府，2023

4. 第七届广东省政府质量奖，广东省人民政府，2022

5. 优秀青年医师奖学金“培育奖”，中国医师协会心血管外科医师分会，2013

6. Lillehei 奖学金“新秀奖”，中华医学会胸心血管外科学分会，2010

7. 湖北省科技进步三等奖，湖北省人民政府，2005