个人简介

1998.09--2003.07 中南大学临床医学专业本科

2003.08--2007.08 江西省萍钢总医院胸外科住院医师

2007.09--2010.07 中山大学临床医学专业硕士研究生

2010.07--2011.08 广州医科大学附属第六医院胸心外科主治医师

2011.09--2014.07 中山大学外科学博士研究生

2014.09--2017.05 广东省心血管病研究所临床医学博士后

2017.06--2019.11 广东省人民医院心外科主治医师

2019.12--2025.11 广东省人民医院心外科副主任医师

2020.02--2023.03 哈佛大学附属波士顿儿童医院访问学者

2015.12--至今    广东省人民医院心外科主任医师

研究方向

先心病的微创手术治疗；肺动脉高压的外科治疗；右心辅助和异种心脏移植

代表性论著

1. Fang Y#, Liu X, Yuan H*. Armour heart: idiopathic calcification in left atrium with severe atrioventricular valve dysfunction. Eur Heart J, 2026 Jan 13:ehaf1112.

2. Ma J#, Han L, Tian M, Tujia Z, Wang K, Fang Y, Chen J, Su Z, Yuan H*. Atrial Isomerism Adversely Impaired both Early and Late Outcomes in Fontan Circulation. Pediatr Cardiol, 2025 Nov 24. Online ahead of print.

3. Wang K#, Meng M, Leng M, Wang Y, Ni J, Yuan H*, Zhang X*, Cao Y*. Protocol for assessing regulatory elements in murine heart using an AAV9-based massively parallel reporter assay. STAR Protoc, 2025 Jun 20;6(2):103782.

4. Wang K#, Han L#, Ma J#, Fang Y, He Y, Liu X, Wen S, Zhuang J*, Yuan H*. Gut microbiota community and metabolic profiles in direct total cavopulmonary connection and Fontan circulation: a cross-sectional study in the single center. Front Microbiol, 2025 Mar 14;16:1539046.

5. Ma J#, Han L#, He Y#, Tian M, Wei P, Tan T, Zhou Z, Gao M, Liu X, Yuan H*, Chen J*. Long-term outcomes of direct total cavopulmonary connection versus extracardiac conduit in Fontan circulation. JTCVS Tech, 2024 Oct 15;29:129-137

6. Liang R#, Abudurexiti N, Wu J, Ling J, Peng Z, Yuan H*, Wen S*. Exosomes and miRNAs in Cardiovascular Diseases and Transcatheter Pulmonary Valve Replacement: Advancements, Gaps and Perspectives. Int J Mol Sci, 2024 Dec 21;25(24):13686.

7. Chen X#, Chen Y, Zhao L, Zou R, Ren Y, Sun X, Zhang X, Yuan H*, Wang Y*. Postoperative systemic arterial hypertension in infants with congenital heart diseases: prevalence and risk factors. Blood Press. 2025 Dec;34(1):2436385.

8. Zhang S#,, Ma J#,, Liu X, Tan T, Xie W, Liu H, Wang H, Qiu H, Wen S, Chen J, Zhuang J, Yuan H*, Cen J*. Outcomes of Rehabilitation Strategies for Pulmonary Atresia with Ventricular Septal Defect: A Single Center's Experience. Rev Cardiovasc Med. 2024 Mar 4;25(3):84.

9. Wang H#, Ma J#, Han L, Tan T, Xie W, Tian M, Tujia Z, Li Y, Liu X, Liu X, Yuan H*, Chen J*. Ventricular Morphology and Outcomes in Fontan Circulation without Hypoplastic Left Heart Syndrome: A Single-Center's Experience. Rev Cardiovasc Med. 2024 May 27;25(6):193.

10. Li C#, Zhu Z#, Yuan H#, Hu Y, Xue Y, Zhong P, Huang M, Ren Y, Kuang Y, Zeng X, Yu H*, Yang X*. Association of preoperative retinal microcirculation and perioperative outcomes in patients undergoing congenital cardiac surgery. Orphanet J Rare Dis. 2023 Dec 8;18(1):385

11. Ma J#, Tan T#, Zhang S, Xie W, He Y, Tian M, Tujia Z, Li X, Liu X, Chen J, Zhuang J, Cen J*, Wen S*, Yuan H*. Long-term outcomes of pulmonary atresia with ventricular septal defect by different initial rehabilitative surgical age. Front Cardiovasc Med. 2023 Oct 16;10:1189954.

12. Xu X#, Jia Q#, Yuan H#, Qiu H#, Dong Y, Xie W, Yao Z, Zhang J, Nie Z, Li X, Shi Y, Zou JY, Huang M, Zhuang J*. A clinically applicable AI system for diagnosis of congenital heart diseases based on computed tomography images. Med Image Anal. 2023 Dec;90:102953.

13. Ma J#, Tan T, Li X, Li J, Zhang Z, Yuan H*. Mitral Valve Replacement Adopting Chimney Technique in Mitral Insufficiency And Extensive Mitral Annular Calcification: A Case Report. Heart Surg Forum. 2022 Oct 12;25(5):E718-E720.

14. Ma J#, Chen J, Tan T, Liu X, Liufu R, Qiu H, Zhang S, Wen S, Zhuang J, Yuan H*. Complications and management of functional single ventricle patients with Fontan circulation: From surgeon's point of view. Front Cardiovasc Med. 2022 Jul 29;9:917059.

15. Li C#, Zhu Z#, Yuan H#, Zhong P, Peng Q, Dong X, Huang M, Liu B, Ren Y, Kuang Y, Zeng X, Yu H*, Yang X*. Improved Retinal Microcirculation After Cardiac Surgery in Patients With Congenital Heart Disease. Front Cardiovasc Med. 2021 Aug 31;8:712308.

16. Li HM#, Mo ZW#, Peng YM#, Li Y#, Dai WP#, Yuan HY#, Chang FJ, Wang TT, Wang M, Hu KH, Li XD, Ning DS, Chen YT, Song YK, Lu XL, Pei Z, Dong YG, Wang ZP, Zhang X, Xu YQ, Wang SM, Ou ZJ*, Ou JS*. Angiogenic and Antiangiogenic mechanisms of high density lipoprotein from healthy subjects and coronary artery diseases patients. Redox Biol. 2020 Sep;36:101642.

17. Li C#, Zhong P#, Yuan H#, Dong X, Peng Q, Huang M, Wu Q, Liu B, Xu M, Kuang Y, Zeng X, Xiao Y, Fang Y, Yu H*, Yang X*. Retinal microvasculature impairment in patients with congenital heart disease investigated by optical coherence tomography angiography. Clin Exp Ophthalmol. 2020 Dec;48(9):1219-1228.

18. Zhang N#, Yuan H#, Chen X, Liu J, Zhou C, Huang M, Jian Q*, Zhuang J*. Hemodynamic of the patent ductus arteriosus in neonates with modified Blalock-Taussig shunts. Comput Methods Programs Biomed. 2020 Apr;186:105223.

19. Liu X#, Yuan H#, Chen J, Cen J, Nie Z, Xu G, Wen S, Zhuang J*. Outcomes following modified extracardiac Fontan procedure of direct total cavopulmonary connection with autologous vessels: a single-centre 10-year experience. Eur J Cardiothorac Surg. 2020 Apr 1;57(4):628-634.

20. Yuan HY#, Zhou CB, Chen JM, Liu XB, Wen SS, Xu G, Zhuang J*. MicroRNA-34a targets regulator of calcineurin 1 to modulate endothelial inflammation after fetal cardiac bypass in goat placenta. Placenta. 2017 Mar;51:49-56.

代表性课题

1. 广东省自然科学基金，2023.06-2027.06，10万元，在研，主持

2. 广州市科技计划重大项目，2023.03-2026.03，50万元，在研，主持

3. 国家重点研发计划项目，2022.12-2026.11，210万元，在研，骨干

4. 国家重点研发计划项目，2022.11-2025.10，168万元，结题，骨干

5. 广东省自然科学基金，2018.05-2022.04，10万元，结题，主持

6. 广东省自然科学基金，2016.06-2019.03，10万元，结题，主持

学术任职

1. 中国医师协会心血管外科分会前沿学组副组长

2. 中国医师协会体外生命支持专业委员会青年委员

3. 中国生物医学工程学会体外循环分会青年委员

4. 广东省医学会心血管外科分会青年委员

5. 广东省妇幼保健学会母婴心血管疾病防治专委会副主任委员

6. 广东省生物医学工程学会胸心血管外科分会委员

7. 广东省胸部疾病协会心血管外科专委会青年委员

8. 《中华胸心血管外科杂志》、《中国胸心血管外科临床杂志》、《中国心血管病研究》和《中国体外循环杂志》等杂志青年编委

执教课程（课程及教材建设）

外科学（胸心外科）

荣誉奖励

中国发明协会一等奖，中国发明协会，2021