个人简介

2000.7-2006.7 四川成都核工业416医院，内科，医师

2005.6.1-2006.6.1 中山大学附属第一医院，肾内科，进修医师

2009.7-2012.12 广东省人民医院，肾内科，住院医师

2013.1-2018.12 广东省人民医院，肾内科，主治医师

2019.1-至今 广东省人民医院，肾内科，副主任医师

2024.7-至今，林芝市人民医院内二科副主任，中组部第十批、第十一批“组团式”医疗援藏人才

研究方向

足细胞损伤和肾脏疾病

心肾综合征防治

肾脏病大数据挖掘

血液透析并发症防治

代表性论著

近10年第一/通讯（含共同）作者

1. Jo P, Zhang R, Zhang Y, Li Z, Wu Y, Zhang S, Lhamo T, Chen Y. Development of a convenient and rapid screening zebrafish model to investigate lethal effects and immunocompromised states of uremic toxins[J]. Ren Fail, 2025; 47(1): 2514183.

2. Guo S, Chen Y(共同第一), Kuang Y, Zhang Q, Wu Y, Xie Z, Chen Z, He Q, Ding F, Liu G, Liao Y, Lu C, Hao L, Sun J, Zhou L, Fang R, Luo Q, Huang H, Cheng Q, Liang X. Developing machine learning-driven acute kidney injury predictive models using non-standard EMRs in resource-limited settings[J]. Med Phys, 2025; 52(10): e70038.

3. Chen Y, Mo Z, Chu H, Hu P, Fan W, Wu Y, Song L, Zhang L, Li Z, Liu S, Ye Z, Liang X. A model for predicting postoperative persistent acute kidney injury (AKI) in AKI after cardiac surgery patients with normal baseline renal function[J]. Clin Cardiol, 2024; 47(1): e24168.

4. Chen Y, Mo Z, Chu H, Hu P, Fan W, Wu Y, Song L, Zhang L, Li Z, Liu S, Ye Z, Liang X. A model for predicting postoperative persistent acute kidney injury (AKI) in AKI after cardiac surgery patients with normal baseline renal function[J]. Clin Cardiol, 2024; 47(1): e24168.

5. Zhang Y, Zhao X, Li C, Yang Y, Li L, Chen Y, Shi Q, Li Z, Wu Y, Zhang L, Li R, Si M, Liang X, Chen Y(共同通讯). Aberrant NAD synthetic flux in podocytes under diabetic conditions and effects of indoleamine 2,3-dioxygenase on promoting de novo NAD synthesis. Biochem Biophys Res Commun. 2023. 643: 61-68.

6. Chen Y, Wu Y, Hu P, Fu X, Liu S, Song L, Dong W, Yu X, Liang X. Psychological impact and implementation of preventative measures in hemodialysis centers during the COVID-19 pandemic: a provincial questionnaire survey in China. Int Urol Nephrol. 2022. 54(3): 601-608.

7. He M, Wu Y, Xie Z, Li Z, Hao L, Liu G, He Q, Liao Y, Ghappar R, Peng H, Xie J, Wei X, Zhang Y, Huang Q, Chen Y (共同通讯), Liang X. Epidemiology of hospitalizations due to pesticide intoxication-associated acute kidney injury in China. Int Urol Nephrol. 2022. 54(2): 377-383.

8. Zeng X, Hu Y, Chen Y (共同第一), Lin Z, Liang Y, Liu B, Zhong P, Xiao Y, Li C, Wu G, Kong H, Du Z, Ren Y, Fang Y, Ye Z, Yang X, Yu H. Retinal Neurovascular Impairment in Non-diabetic and Non-dialytic Chronic Kidney Disease Patients. Front Neurosci. 2021. 15: 703898.

9. Xu L, Wu Y, Chen Y (共同第一), Li R, Wang Z, Li Z, Liu G, Yu L, Shi W, Liang X, China collaborative study on AKI (CCS-AKI). Is acute kidney injury age-dependent in older adults: an observational study in two centers from North China. BMC Geriatr. 2021. 21(1): 7.

10. Zhang H, Chen YH (共同第一), Xie Z. Contact allergy due to platinum siloxane complex in elastic compression stockings for varicose veins. Contact Dermatitis. 2020. 83(5): 427-429.

11. Wu Y, Hao W, Chen Y (共同第一), Chen S, Liu W, Yu F, Hu W, Liang X. Clinical features, risk factors, and clinical burden of acute kidney injury in older adults. Ren Fail. 2020. 42(1): 1127-1134.

12. Xu L, Chen Y (共同第一), Xie Z, He Q, Chen S, Wang W, Liu G, Liao Y, Lu C, Hao L, Sun J, Shi W, Liang X. High hemoglobin is associated with increased in-hospital death in patients with chronic obstructive pulmonary disease and chronic kidney disease: a retrospective multicenter population-based study. BMC Pulm Med. 2019. 19(1): 174.

13. Xie Z, Mo Z, Chen J, Wu Y, Chen S, Li Z, Ye Z, Liang H, Liu S, Fu L, Chen Y (共同通讯), Liang X. Prevalence of Concomitant Coronary Artery Disease and Its Impact on Acute Kidney Injury for Chinese Adult Patients Undergoing Valvular Heart Surgery. Cardiology. 2019. 144(1-2): 60-68.

14. Chen Y, Zhao X, Li J, Zhang L, Li R, Zhang H, Liao R, Liu S, Shi W, Liang X. Amino acid starvation promotes podocyte autophagy through mammalian target of rapamycin inhibition and transcription factor EB activation. Mol Med Rep. 2018. 18(5): 4342-4348.

15. Wu Y, Chen Y (共同第一), Li S, Dong W, Liang H, Deng M, Chen Y, Chen S, Liang X. Value of electronic alerts for acute kidney injury in high-risk wards: a pilot randomized controlled trial. Int Urol Nephrol. 2018. 50(8): 1483-1488.

16. Wu Y, Chen Y (共同第一), Chen S, He Y, Liang H, Dong W, Liang X. Attitudes and practices of Chinese physicians regarding chronic kidney disease and acute kidney injury management: a questionnaire-based cross-sectional survey in secondary and tertiary hospitals. Int Urol Nephrol. 2018. 50(11): 2037-2042.

17. Zhao X, Chen Y (共同第一), Tan X, Zhang L, Zhang H, Li Z, Liu S, Li R, Lin T, Liao R, Zhang Q, Dong W, Shi W, Liang X. Advanced glycation end-products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB. J Pathol. 2018. 245(2): 235-248.

18. Mo L, Chen Y (共同第一), Li Z, Xu L, Dong W, Zhang L, Liang H, Li R, Tao Y, Shi W, Liang X. Red blood cell distribution width as a marker of cerebral infarction in hemodialysis patients. Ren Fail. 2017. 39(1): 712-718.

19. Chen Y, Li Z, Mo L, Feng Z, Li R, Shi W, Liang X. Eosinophilia in Peritoneal Effluent Due To a Levonorgestrel-Releasing Intrauterine System in a Woman on Peritoneal Dialysis. Perit Dial Int. 2017. 37(3): 349-350.

20. Chen Y, Cai L, Du Z, Xu J, Tan N, Ye Z, Liu S, Dong W, Shi W, Liang X. Dipstick proteinuria is a prognostic indicator of short-term mortality in patients with heart failure. Int J Cardiol. 2017. 230: 59-63.

21. Xie Z, Zhang M, Xiong W, Wan HY, Zhao XC, Xie T, Lei H, Lin ZC, Luo DS, Liang XL, Chen YH. Immunotolerant indoleamine-2,3-dioxygenase is increased in condyloma acuminata. Br J Dermatol. 2017. 177(3): 809-817.

22. Tan X, Chen Y (共同第一), Liang X, Yu C, Lai Y, Zhang L, Zhao X, Zhang H, Lin T, Li R, Shi W. Lipopolysaccharide-induced podocyte injury is mediated by suppression of autophagy. Mol Med Rep. 2016. 14(1): 811-818.

23. Chen Y, Li Z, Liang X, Zhang M, Zhang Y, Xu L, Zhong L, Shi W. Effect of individual health education on hyperphosphatemia in the Hakkas residential area. Ren Fail. 2015. 37(8): 1303-1307.

代表性课题

1. 足细胞B7-1信号通过诱导IDO促进NAD+从头合成对保护高原糖尿病肾病的效应及机制研究，西藏自治区自然科学基金重点项目，2025.4-2028.3，23万，在研，主持

2. 自动肾功能判读系统对提升医院获得性急性肾损伤管理和预后的综合效应研究，西藏自治区自然科学基金组团援藏项目，2025.1-2026.12，9万，在研，主持

3. 转录因子AhR通过促进树突状细胞IDO介导尿毒症免疫耐受的机制及作用. 国家自然科学基金，2018.1-2021.12，55万，结题，主持

4. RIP3激酶介导重症急性肾损伤中自噬流障碍的机制. 广东省自然科学基金自由申请项目，2016.6.1-2019.6.1，10万，结题，主持

5. 肾脏疾病的社区健康教育及科普人员培训.广东省科技发展专项资金（协同创新与平台环境建设，2017.1.1-2020.12.31，30万，结题，主持

学术任职

1. 中关村血液净化创新联盟-心肾代谢疾病共管共治专委会，秘书长

2. 中关村血液净化创新联盟-肾心共治专委会，秘书长

3. 广东省生物医学工程学会血液净化分会，副主任委员

4. 中国研究型医院学会血液净化专业委员会委员

5. 广东省药学会第一届变态反应专委会常委

执教课程（课程及教材建设）

1. 内科学

荣誉奖励

1. 广东省杰出青年医学人才

2. 羊城好医生