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个人简介
1985.09--1990.06 武汉市同济医科大学临床医学专业本科
2001.09--2004.06 广东省心血管病研究所心内科专业硕士研究生
2007.09--2012.06 广东省心血管病研究所心内科专业博士研究生
1990.07--1998.11 广东省人民医院、广东省心血管病研究所心内科住院医师
1998.12--2004.11 广东省人民医院、广东省心血管病研究所心内科主治医师
2004.12--2009.11广东省人民医院、广东省心血管病研究所心内科副主任医师
2009.12--至今 广东省人民医院、广东省心血管病研究所心内科主任医师
2005.01--至今 广东省人民医院心内三科 科主任
研究方向
心力衰竭、心肌病、代谢性心血管疾病临床及基础研究,新药临床研究
代表性论著
[1] Li L, Zhou Y, Deng C, Sheng J, Peng D, Ling Z, Wang L, Dai C, Huang K, Lian Q, Yu Z, Yang H, Hu Y, Dong Y, Wang N, Wang Z, Zhang W, Han X, Yao Z, Liu Q, Liang Y, Xu B, Wang Y, Zhong T, Chen J. Recaticimab in adult heterozygous familial hypercholesterolaemia (REMAIN-3): a multicentre, randomized, double-blind, placebo-controlled Phase 3 study. Cardiovasc Res. 2025 Oct 24;121(12):1856-1864. (IF=13.3)
[2] Qiu W, Xiong C, Zeng K, Li L, Gao Z. The role of cardiovascular health in the associations between insulin resistance, future cardiovascular disease, and all-cause mortality. Postgrad Med J. 2025 Sep 18;101(1200):1025-1033. (IF=2.7)
[3] Tian Z, Li X, Li L, Zhang Q, Wang J, Shi Y, Peng D, Yang P, Ma W, Wang F, Jin W, Cheng X, Chen YM, Zhong Y, Barrett YC, Zheng J, Zhang S. Effect of Mavacamten on Echocardiographic Features in Chinese Patients with Obstructive Hypertrophic Cardiomyopathy: Results from the EXPLORER-CN Study. Cardiol Ther. 2025 Jun;14(2):267-282. (IF=2.7)
[4] Wei HQ, Wang J, Liang Y, Xia S, Li L, Zhong L. Prophylactic implantation of cardioverter-defibrillator in patients with advanced light-chain amyloidosis-A pilot study. J Arrhythm. 2025 Apr 20;41(2):e70068. (IF=1.7)
[5] Yao Y, Zhou Z, Geng T, Cai A, Li T, Yang J, Chen J, Li L. Long-term cost-effectiveness of transcatheter mitral valve repair in HF patients with secondary mitral regurgitation. ESC Heart Fail. 2024 Aug;11(4):2023-2032. (IF=3.7)
[6] Yu Y, Liu J, Zhang L, Ji R, Su X, Gao Z, Xia S, Li J, Li L. Perceived Economic Burden, Mortality, and Health Status in Patients With Heart Failure. JAMA Netw Open. 2024 Mar 4;7(3):e241420. (IF=13.8)
[7] Yao Y, Wang B, Geng T, Chen J, Chen W, Li L. The association between TyG and all-cause/non-cardiovascular mortality in general patients with type 2 diabetes mellitus is modified by age: results from the cohort study of NHANES 1999-2018. Cardiovasc Diabetol. 2024 Jan 28;23(1):43.(IF=10.6)
[8] Qiu W, Cai A, Xiao X, Gao Z, Feng Y, Li L. Diabetes mellitus status modifies the association between N-terminal B-type natriuretic peptide and all-cause mortality risk in ischemic heart failure: a prospective cohort study. Diabetol Metab Syndr. 2023 Apr 11;15(1):72.(IF=3.9)
[9] Qiu W, Cai A, Xiao X, Gao Z, Feng Y, Li L. Association of Functional Tricuspid Regurgitation and All-Cause Mortality in Ischemic Heart Failure Varies by Left Atrial Size: A Prospective Cohort Study. Am J Cardiol. 2023 Oct 15;205:50-57. (IF=2.1)
[10] Qiu W, Cai A, Li L, Feng Y. Lagging behind the Western countries: the knowledge gaps of gender differences in heart failure in Asia. ESC Heart Fail. 2023 Oct;10(5):2797-2806.(IF=3.7)
[11] Cai A, Qiu W, Xia S, Zhou Y, Chen J, Tan N, Gao Z, Ou Y, Li W, Liao Y, Dong Y, Li X, Zhou J, Feng Y, Li L, Yang J. Sex-specific characteristics and outcomes in hospitalized heart failure with preserved ejection fraction: the China Cardiovascular Association Database-Heart Failure Center Registry. Eur Heart J. 2023 Nov 21;44(44):4715-4718. (IF=39.9)
[12] Wu Z, Xu L, Cai A, Chen W, Xia S, He X, Qiu W, Xiao X, Gao Z, Chen J, Li L. The Prognostic Significance of Chronic Kidney Disease on the All-Cause Death of Ischemic Heart Failure in the Chinese Population: A Prospective Cohort Study. Cardiorenal Med. 2022;12(2):61-70.(IF=2.9)
[13] Cai A, Qiu W, Xiao X, Xia S, Zhou Y, Li L. All-Cause Mortality in Ischemic Heart Failure Patients with Functional Mitral Regurgitation Undergoing Percutaneous Coronary Intervention. Am J Cardiol. 2022 May 15;171:55-64.(IF=2.1)
[14] Cai A, Chen R, Pang C, Liu H, Zhou Y, Chen J, Li L. Machine learning model for predicting 1-year and 3-year all-cause mortality in ischemic heart failure patients. Postgrad Med. 2022 Nov;134(8):810-819. (IF=2.8)
[15] Qiu W, Xiao X, Cai A, Gao Z, Li L. Pulse pressure and all-cause mortality in ischaemic heart failure patients: a prospective cohort study. Ann Med. 2022 Dec;54(1):2701-2709.(IF=4.3)
[16] Cai A, Qiu W, Zhou Y, Feng Y, Chen J, Xia S, Li W, Liao Y, Li X, Zhou J, Wang H, Jin W, Zhang Q, Sun Z, Chen M, Wang J, Kong H, Zhang Y, Dong W, Bai L, Xu D, Yuan J, Liu C, Jiang M, Xu Y, Li L, Dong Y, Yang J. Clinical characteristics and 1-year outcomes in hospitalized patients with heart failure with preserved ejection fraction: results from the China Cardiovascular Association Database-Heart Failure Center Registry. Eur J Heart Fail. 2022 Nov;24(11):2048-2062. (IF=17.3)
[17] Li M, Xia S, Xu L, Tan H, Yang J, Wu Z, He X, Li L. Genetic analysis using targeted next-generation sequencing of sporadic Chinese patients with idiopathic dilated cardiomyopathy. J Transl Med. 2021 May 3;19(1):189.(IF=7.5)
[18] Song F, Zhou Y, Zhang K, Liang YF, He X, Li L. The role of the plasma glycosylated hemoglobin A1c/Apolipoprotein A-l ratio in predicting cardiovascular outcomes in acute coronary syndrome. Nutr Metab Cardiovasc Dis. 2021 Feb 8;31(2):570-578. (IF=3.7)
[19] Cai A, Wu Z, Xu L, Xia S, He X, Zhang Y, Chen J, Zhou Y, Li L. Association of anaemia and all-cause mortality in patients with ischaemic heart failure varies by renal function status. ESC Heart Fail. 2021 Jun;8(3):2270-2281.(IF=3.7)
[20] Xia S, Qiu W, Cai A, Kong B, Xu L, Wu Z, Li L. The association of lipoprotein(a) and intraplaque neovascularization in patients with carotid stenosis: a retrospective study. BMC Cardiovasc Disord. 2021 Jun 9;21(1):285.(IF=2.3)
代表性课题
1. TMAO激活TRAFs/NF-κB信号通路调控M1型巨噬细胞极化促进缺血性心衰心肌纤维化的机制研究,2022.04-2024.03,5万元,结题,主持
2. 集束化治疗模式探讨MSCs移植治疗心肌梗死大鼠疗效研究,2016.06-2020-06,10万元,结题,主持
3. 急性冠脉综合征患者优化抗栓治疗策略研究,2015.01-2018.12,20万元,结题,主持
学术任职
中华医学会心血管病分会心肌病学组委员
中国医师协会心力衰竭专业委员会常委
中国医师协会心血管内科医师分会罕见心血管疾病学组委员
中国健康促进与教育协会心肺血管健康分会常委
中国疾病预防控制中心慢性非传染性疾病预防控制中心“心力衰竭全程管理中心工作委员会”副秘书长
国家心血管病专家委员会心力衰竭专委会常委
国家卫健委健康科普专家库成员
广东省医学会心血管病分会心力衰竭学组副组长
广东省医师协会心力衰竭专业委员会主任委员
广东省女医师协会心力衰竭及代谢性心血管疾病专委会主任委员
广东省女医师协会心血管病医防融合分会主任委员
广东省抗癌协会整合肿瘤心脏病学专业委员会副主委
执教课程(课程及教材建设)
1. 诊断学
2. 内科学
荣誉奖励
1. 2023年心肌病规范化诊疗建设推动奖,苏州工业园区东方华夏心血管健康研究院,苏州工业园区心馨心血管健康基金会,2023
2. 2023年心衰中心“科研推动奖”,苏州工业园区东方华夏心血管健康研究院,心衰中心工作委员会,2023
3. 2023年度学科中心科研成果推动奖,苏州工业园区东方华夏心血管健康研究院,苏州工业园区心馨心血管健康基金会,2023
4. 2022年心衰中心“学术培训推动奖”,心衰中心联盟,心血管健康联盟,苏州工业园区东方华夏心血管健康研究院,心衰中心专家委员会,2022
5. 2022年心衰中心“模范专家”荣誉称号,2022年心衰中心“模范专家”荣誉称号,2022
6. 2022年心衰中心“科研推动奖”,心衰中心联盟,心血管健康联盟,苏州工业园区东方华夏心血管健康研究院,心衰中心专家委员会,2022
7. 2021年心衰中心“模范专家”荣誉称号,2021年心衰中心“模范专家”荣誉称号,2021