个人简介

1993.08--1998.07 中国医科大学临床医学专业本科

1998.08--2003.07 中国医科大学内分泌及代谢病学专业博士研究生

2003.07--2006.06 中国医科大学附属第一医院内分泌科讲师、主治医师

2006.06--2009.06 中国医科大学附属第一医院内分泌科副教授、副主任医师

2009.06--2020.07 中国医科大学附属第一医院内分泌科教授、主任医师

2020.08--至今    广东省人民医院内分泌科主任医师

研究方向

激素作用调控、内分泌及代谢病及其共病、肿瘤与内分泌代谢

代表性论著

1. Sun Y#, WangH#, Li L#, Wang J#, Chen W#, Peng L#, Hu P, Yu J, Cai X, Yao N, Zhou Y, Wang J, Wang Y, Qian L, Ge W, Chen M, Yang F, Gui Z, Sun W, Wang Z, Ge M, He Y, Wang G, Zhao Y, Chen H, Wu X, Du Y, Wei W, Wu F, Luo D, Lin X, Zheng H, Zhu X, Wei B, Shen J, Yao J, Yuan Z, Liu T, Pan J, Zhang Y, Lv Y, Guo Q, Wu Q, Gong T, Chen T, Zheng S, Zhu J, Liu H, Cheng G, Han H, Selvarajan S, Xing M, Kakudo K, Alexander E, Wu Y, Wang Y, Xu D, Zhang H, Nie X, Kon OL, Iyer NG, Liu Z, Zhu Y*, Guan H*, Guo T*; We-TEC Investigators. A protein-based classifier for differentiating follicular thyroid adenoma and carcinoma. EMBO Mol Med. 2025 Jul;17(7):1519-1538. (IF 8.3)

2. Yang Y#, Lyu X#, Fu J#, Lei J, Wu H, Zhao C, Liu M, Hu X, Li J, Wang Y, He Y, Peng Z, Zhang Y, Zhang H, Wang Q, Shen H, Zhang Y, Yan D, Ma X*, Guan H*. Incidental hyperglycemia in women at reproductive age and its association with thyrotropin levels: A population-based cohort study in China. Diabetes Res Clin Pract. 2025 Jun 24;226:112345. (IF 7.4)

3. Zong D#, Sun B#, Ye Q, Cao H, Guan H*. Circadian Gene BMAL1 Regulation of Cellular Senescence in Thyroid Aging. Aging Cell. 2025 May 28:e70119. (IF 7.1)

4. Yu C,# Feng A#, Zou X#, Chen S, Dai L, Cui Q, Kuang X, She G, Ma Y, Guan H*, Li J*. Birth weight, cardiovascular health, and microvascular xomplications in individuals with diabetes mellitus. Diabetes Metab J. 2025 May 23. (IF 8.5)

5. Cai X#, Sun R#, Yang L#, Yao N, Sun Y, Zhang G, Ge W, Zhou Y, Gui Z, Wang Y, Zheng H, Xu D, Zhao Y, Nie X, Liu Z, Zhang H, Hu P, Cheng H, Xue Z, Wang J, Yu J, Chen C, Luo D, Zhu J, Liu T, Zhang Y, Wu Q, Guo Q, Chen W, Wang J, Wei W, Lin X, Yao J, Wang G, Peng L, Liu S, Wang Z, Liu H, Wang J, Wu F, Yuan Z, Gong T, Lv Y, Xiang J, Zhu Y, Xie L*, Ge M*, Guan H*, Guo T*; We-TEC Investigators. Proteomic analysis reveals modulation of key proteins in follicular thyroid cancer progression. Chin Med J (Engl). 2025 May 21. (IF 7.3)

6. Yin Q#, Zhu T#, Song D, Fang S, Zhou H*, Guan H*. Soluble immune checkpoints associated with disease activity and treatment response in GD and TED. J Clin Endocrinol Metab. 2025 May 19; 110(6): 1537-1549. (IF 5.1)

7. Xie Z#, Yu C#, Cui Q, Zhao X, Zhuang J, Chen S, Guan H*, Li J*. Global burden of the key components of Cardiovascular- Kidney-Metabolic syndrome. J Am Soc Nephrol. 2025 Mar 5. (IF 9.4)

8. Yang S, Huang Z, Zhang Y, Li Y, Zhou Y, Guan H*, Fan J*. Association of maternal thyroglobulin antibody with preterm birth in euthyroid women. J Clin Endocrinol Metab. 2025 Feb 25:dgaf118. (IF 5.1)

9. Lin S#, Qiu X#, Fu X, Zhang S, Tang C, Kuang J*, Guan H*, Lai S*. SNRK modulates mTOR-autophagy pathway for liver lipid homeostasis in MAFLD. Mol Ther. 2024 Nov 9: S1525-0016(24)00743-3. (IF 12.0)

10. Zhang S#, Liu E#, Lai S, Kuang J, Guan H*. Sympathetic paraganglioma in the pericardium with paraganglioma syndrome 3: Multimodality imaging findings. Chin Med J (Engl). 2024 Nov 5;137(21):2641-2643. (IF 7.3)

11. Li C#, Zhang J#, Dionigi G, Liang N, Guan H*, Sun H*. Uncovering the connection between obesity and thyroid cancer: the therapeutic potential of adiponectin receptor agonist in the AdipoR2-ULK axis. Cell Death Dis. 2024 Sep 30;15(9):708. (IF 9.6)

12. Zhang Z^#, Wu Y^#, Fu J^#, Yu X, Su Y, Jia S, Cheng H, Shen Y, He X, Ren K, Zheng X, Guan H*, Rao F*, Zhao L*. Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis. Nat Commun.2024 May 15;15(1):4108. (IF 14.7)

13. Yan K^#, Liu QZ^#, Huang RR^#, Jiang YH, Bian ZH, Li SJ, Li L, Shen F, Tsuneyama K, Zhang QL, Lian ZX, Guan H*, Xu B*. Spatial transcriptomics reveals prognosis-associated cellular heterogeneity in the papillary thyroid carcinoma microenvironment. Clin Transl Med. 2024 Mar;14(3):e1594. (IF 7.9)

14. Fu J, Guan H*. The Impact of Salt Iodization on the Occurrence of Hyperthyroidism: Evidence From General Populations to Pregnant Women. J Clin Endocrinol Metab. 2024 Feb 20;109(3):e1299-e300. (IF 5.0)

15. Sui F, Chen P, Feng C, Yang Q, Zhang S, Ji M, Wang Y, Guan H*, Xing M*, Hou P*. A Feedback Loop Involving Exosomal miR-146a and NG2 to Propel the Development and Progression of Hypothyroidism. Thyroid. 2023 Sep;33(9):1064-77. (IF 6.6)

16. Wang Z, Guan H*. Hear the Patient's Voice Regarding Implementation of Thyroid Cancer Active Surveillance in China. Thyroid. 2023 Jul;33(7):782-4. (IF 6.6)

17. Hou X^#, Guan H^#, Sun S, Shi Y, Li C, Liu A, Li Y, Gao X, Hou Y, Yang Y, Li Y*, Shan Z, Teng W. Outcomes of Early-Pregnancy Antithyroid Drug Withdrawal in Graves' Disease: A Preliminary Prospective Follow-Up Study. Thyroid. 2022 Aug;32(8):983-989. (IF 6.568)

18. Yang Y^#, Guo T^#, Fu J^#, Zhao J*, Wang Y, He Y, Peng Z, Zhang Y, Zhang H, Zhang Y, Wang Q, Shen H, Zhang Y, Yan D, Ma X*, Guan H*. Association of Preconception Thyrotropin Levels With Fecundability and Risk of Spontaneous Abortion in China. JAMA Netw Open. 2022 Aug 1;5(8):e2228892. (IF 13.353)

19. Zhang P^#, Guan H^#, Yuan S^#, Cheng H, Zheng J, Zhang Z, Liu Y, Yu Y, Meng Z, Zheng X, Zhao L*. Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors. Nat Commun. 2022 Mar 24;13(1):1588. (IF 17.694)

20. Su X, Chen D, Zhu L, Jia H, Cai J, Li P, Han B, Wang D, Li H, Fan J, Gu M, Zhou Y, Guan H*, Wei W*. SGSM2 inhibits thyroid cancer progression by activating RAP1 and enhancing competitive RAS inhibition. Cell Death Dis. 2022 Mar 9;13(3):218. (IF 9.685)

21. Yang S^#, Lai S^#, Wang Z, Liu A, Wang W*, Guan H*. Thyroid Feedback Quantile-based Index correlates strongly to renal function in euthyroid individuals. Ann Med. 2021 Dec;53(1):1945-1955. (IF 5.348)

22. Yang Y^#, Guo T^#, Fu J^#, Kuang J, Wang Y, Zhang Y, Zhang H, He Y, Peng Z, Wang Q, Shen H, Zhang Y, Yan D, Ma X*, Guan H*. Preconception Thyrotropin Levels and Risk of Adverse Pregnancy Outcomes in Chinese Women Aged 20 to 49 Years. JAMA Netw Open. 2021, 4(4): e215723. (IF 13.353)

代表性课题

1. 国家重大科技专项课题，2025.02-2029.01，880万元，在研，主持

2. 国家重点研发计划课题，2024.12-2029.11，500万元，在研，主持

3. 国家自然科学基金面上课题，2024.01-2027.12，49万元，在研，主持

学术任职

1. 中华医学会糖尿病学分会，委员

2. 中华预防医学会甲状腺疾病防治专业委员会，常委

3. 中国抗癌协会甲状腺癌专业委员会，常委

4. 广东省医学会内分泌学分会，副主任委员

5. 《Thyroid》杂志和《Endocrine》杂志，副主编

执教课程（课程及教材建设）

1. 讲授《内科学》本科大课

2. 参编教材《内分泌内科学》（供专业学位研究生及专科医师用）

荣誉奖励

1. 天津市科技进步一等奖，天津市人民政府，2021

2. 妇幼健康科学技术奖科技成果奖一等奖，中国妇幼健康研究会，2023

3. 华夏医学科技奖三等奖，中国医疗保健国际交流促进会，2023