个人简介

2006.09--2010.06 南昌大学生物技术专业 本科

2010.09--2013.06 中山大学动物学专业 硕士研究生

2013.07--2015.07 中山大学中山医学院寄生虫学教研室研究助理

2015.08--2018.06 中山大学肿瘤防治中心分子医学专业 博士研究生

2018.07—2021.07 中山大学肿瘤防治中心博士后

2021.08--2023.12 广东省人民医院病理科助理研究员

2024.01--今 广东省人民医院病理科副研究员

研究方向

肿瘤免疫微环境

代表性论著

1. Yan Mei^#, Xiumei Wang^#, Ji Zhang^#, Zhigang Liang, Junjie He, Chunliu Huang, Jing Liao, Yingzhao Wang, Yuan Hui, Yongyi Feng, Hongyu Li, Xiuying Liu, Lingdan Chen, Wei Yi, Xi Chen, Hong-Min Bai, Jialiang Xu, Xianwen Ren, Qibin Leng*, Jun Chen*, Guangshuai Jia*. Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response. Nature Cancer. 2023, 4(9):1273-1291.

2. Feifei Luo^#, Yan Mei^#, Yanwen Li, Jiahao Yang, Shaoyan Xi, Endong Cao, Cong Shen, Dexiang Zhou, Peng Wang, Dong Zhou, Haiping Cai. CAF-derived LRRC15 orchestrates macrophage polarization and limits PD-1 immunotherapy efficacy in glioblastoma. Neuro-oncology. 2025, noaf157. doi: 10.1093/neuonc/noaf157.

3. Congcong Zhang^#, Haiping Cai^#, Mengnan Ye^#, Le Wang, Weiwei Liu, Qun Huang, Xingsi Peng, Guanquan Mao*, Qingling Zhang*, Yan Mei*. TCF7 functions as a prognostic biomarker in bladder cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling. Molecular and Cellular Biochemistry. 2025, 480(7):4135-4148.

4. Yan Mei^#, Weiwei Xiao^#, Hao Hu^#, Guanming Lu^#, Lingdan Chen^#, Zhun Sun, Mengdie Lü, Wenhui Ma, Ting Jiang, YuanHong Gao, LiRen Li, Gong Chen, Zifeng Wang, Hanjie Li, Duojiao Wu*, Pinghong Zhou*, Qibin Leng*，Guangshuai Jia*. Single-cell analyses reveal suppressive tumor microenvironment of human colorectal cancer. Clinical and Translational Medicine, 2021, 11(6):e422.

5. Huanjun Wang^#, Yan Mei^#, Cheng Luo^#, Qun Huang^#, Zifeng Wang^#, Guanming Lu, Lingdan Chen, Zhun Sun, Chaowen Huang, Zhiwen Yang, Junxing Chen, Weiguo Yin, Chaonan Qian, Lingwu Chen*, Qibin Leng*, Yan Guo*, Guangshuai Jia*. Single-cell analyses reveal mechanisms of cancer stem cell maintenance and epithelial-mesenchymal transition for human bladder cancer recurrence. Clinical Cancer Research. 2021, 27(22):6265-6278.

6. Yan Mei^#, Yinghe Li^#, Xiaochun Yang^#, Chao Zhou, Zhijian Li, Xiaobin Zheng, Jiacong Ye, Cheng Li, Xuanhong Zhang, Jianmin Yuan, Huiqiang Huang, Wei Fan, Weiguang Zhang*, Musheng Zeng*, Guokai Feng*. An optimized integrin α6-targeted peptide for positron emission tomography/ magnetic resonance imaging of pancreatic cancer and its precancerous lesion. Clinical and Translational Medicine, 2020, 10(4):e157.

7. Yan Mei, Junping Yang, Chaonan Qian*. For robust big data analyses: a collection of 150 important pro-metastatic genes, Chinese Journal of Cancer, 2017, 36(1):16.

8. Yan Mei^#, Mingdian Wang^#, Guanming Lu^#, Jiangchao Li, Lixia Peng, Yanhong Lang, Mingming Yang, Lingbi Jiang, Changzhi Li, Lisheng Zheng, Zhijie Liu, Dehuan Xie, Lingling Guo, Bijun Huang, Musheng Zeng, Yanxia Shi, Chaonan Qian*. Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity. Cancer Cell International. 2021, 21:97.

9. Yan Mei, Junping Yang, Yanhong Lang, Lixia Peng, Mingming Yang, Qing Liu, Dongfang Meng, Lisheng Zheng, Yuanyuan Qiang, Liang Xu, Changzhi Li, Wenwen Wei, Ting Niu, Xingsi Peng, Qin Yang, Fen Lin, Hao Hu, Hongfa Xu, Bijun Huang, Lijing Wang, Chaonan Qian*. Global Expression Profiling and Pathway Analysis of Mouse Mammary Tumor Reveals Strain and Stage Specific Dysregulated Pathways in Breast Cancer Progression, Cell Cycle, 2018, 17(8):963-973.

10. Rui Zeng^#, Zhihao Lin^#, Feiyan Feng^#, Yanyan Li, Weiwei Liu, Wenting He, Yongjun Huang, Xingtao Lin, Yan Mei*, Hongmei Wu*, Qingling Zhang*. Metabolic alterations and immune heterogeneity in gastric cancer metastasis. iScience. 2025, 28(5):112296.

代表性课题

1. 国家自然科学基金（面上项目），2026.01-2029.12，49.0 万，在研，主持

2. 卫健委四大慢病国家科技重大专项子课题，2025.08-2029.07，20.0 万，在研，子课题主持。

3. 广东省自然科学基金（面上项目），2024.01-2026.12，15.0万，在研，主持。

4. 国家自然科学基金（青年项目），2023.01-2025.12，30.0万，资助期满，主持。

5. 第 66 批次中国博士后面上资助，2020.01-2021.12，8.0 万，已结题，主持。

学术任职

1. 中国抗癌协会肿瘤微环境专业委员，委员

广东省精准医学应用学会临床生物信息分会, 委员

执教课程（课程及教材建设）

1. 免疫学前沿