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个人简介
1998.09--2003.07 中国医科大学临床医学专业本科
2003.09--2006.06 中山大学附属第二医院皮肤病与性病专业硕士研究生
2008.09--2011.06 中山大学附属第一医院内科学(肾脏病学)博士研究生
2011.07--2014.12 广东省人民医院肾内科住院医师
2014.08--2019.10 广东省人民医院肾内科主治医师
2019.10--2024.12 广东省人民医院老年医学研究所肾内科副主任医师,副教授
2025.01--至今 广东省人民医院 老年医学研究所肾内科主任医师,教授
研究方向
CKD进展免疫机制、腹膜透析相关并发症免疫机制
代表性论著
1. Qixing Yu#, Ganyuan He, Zhi Zhao, Jiayi Chen, Qiqi Huang, Wenke Hao, Xiangbin Mi, Wenxue Hu*. Comparison of clinical features between patients with and without renal involvement in IgG4-related disease. Clin Exp Med. 2025;25(1):95.
2. Zheng Siqi#, Deng Shanshan#, Yin Yan, Li Guanglan, He Ganyuan, Li Jiaying, He Jintao, He Hui, Hu Wenxue*, Liang Xinling*. Single-Cell RNA Sequencing Reveals Peritoneal Environment and New Insights into Fibrosis in a Continuous Ambulatory Peritoneal Dialysis Patient: A Longitudinal Self-Controlled Study from Dialysis Initiation to 3-Year Follow-Up. Kidney Dis (Basel). 2025;11(1):835-856.
3. Ganyuan He#, Jiayi Chen#, Wenke Hao*, Wenxue Hu*. Causal effect of gut microbiota and diabetic nephropathy: a Mendelian randomization study. Diabetology & Metabolic Syndrome, 2024.04,16(1):89.
4. Jiayi Chen#, Feng Yu#, Ganyuan He, Wenke Hao*, Wenxue Hu*. A nomogram based on peripheral lymphocyte for predicting 8-year survival in patients with prostate cancer: a single-center study using LASSO-cox regression, BMC Cancer, 2024.01,24(1):254.
5. Wenxue Hu#, Guanglan Li#, Wei Dong, Peng He, Wei Liu, Yanhua Wu, Huaban Liang, Feng Wen, Feng Yu, Yan Yin, Zhiming Ye, Wenke Hao, Xingling Liang*. Single-cell sequencing reveals peritoneal environment and insights into fibrosis in CAPD patients. iScience. 2023;26(4):106336.
6. Guanglan Li#, Wenke Hao#, Wenxue Hu*. Transcription factor PU.1 and immune cell differentiation. Int J Mol Med 2020;46(6):1943-1950.
7. Jieshan Lin#, Bin Tang, Ganyuan He, Zhanwu Feng, Wenke Hao, Wenxue Hu*. B lymphocytes subpopulations are associated with cardiac remodeling in elderly patients with advanced chronic kidney disease. Exp Gerontol. 2022;163:111805.
8. Wenxue Hu#, Jieshan Lin#, Wei Liu, Xiaowu Fang, Yanhua Wu, Feng Yu, Xinling Liang*, Hao W*. M2a and M2b macrophages predominate in kidney tissues and M2 subpopulations were associated with the severity of disease of IgAN patients. Clin Immunol. 2019; 205:8-15.
代表性课题
1. 国家自然科学基金面上项目, 2025/01-2028/12,49万元,在研,主持。
2. 国家自然科学基金面上项目, 2023/01-2026/12,52万元,在研,主持。
3. 国家自然科学基金青年项目, 2018/01-2020/12,21万元,已结题,主持。
4. 广东省自然科学基金面上项目, 2025/01-2027/12,15万元,在研,主持。
5. 广东省自然科学基金面上项目, 2019/10-2022/9,10万元,在研,主持。
6. 广州市科技计划项目,2022/04-2025/3,5万元,结题,主持。
7. 广东省医学科研基金面上项目, 2019/7-2021/6,1万元,结题,主持。
学术任职
1. 中国医师协会老年医学医师分会青年学组 委员
2. 广东省临床医学会肾脏病精准诊疗专委会 委员
执教课程(课程及教材建设)
内科学